1.14.99.1	arachidonate + 2 O2	-	
1.14.99.1	arachidonate + AH2 + 2 O2	-	
1.14.99.1	arachidonate + AH2 + O2	-	
1.14.99.1	arachidonate + reduced acceptor + O2	-	
1.14.99.1	additional information	first step in prostaglandin synthesis	
1.14.99.1	additional information	enzyme has a central position in prostanoic metabolism: first step in formation of prostaglandins and thromboxanes, the conversion of arachidonic acid to prostaglandin endoperoxides G and H	
1.14.99.1	additional information	the expression of PGHS-2 may be involved in inhibiting progesterone production	
1.14.99.1	additional information	prostaglandin synthesis within the fetal central nervous system is critical for the the modulation of hypotension-induced fetal ACTH secretion involving PGHS-2, overview	
1.14.99.1	additional information	dopamine precursor L-dihydroxyphenylalanine, i.e. L-DOPA, and metabolites dihydroxyphenylacetic acid, homovanillic acid, and 3-methoxytyramine may serve as substrates for prostaglandin H synthase-catalyzed bioactivation to free radical intermediates	
1.14.99.1	additional information	PGHS-2 also shows cyclooxygenase activity	
1.14.99.1	additional information	activity with arachidonate in presence of glutathione leads to formation of malondialdehyde and (15S)-8-iso-prostaglandin F2alpha	
1.14.99.1	prostaglandin G2 + AH2	-