1.14.15.6	(20R,22R)-20,22-dihydroxy-cholesterol + 2 reduced adrenodoxin + O2	-	
1.14.15.6	(22R)-22-hydroxycholesterol + 2 reduced adrenodoxin + O2	-	
1.14.15.6	cholesterol + 2 reduced adrenodoxin + O2	-	
1.14.15.6	cholesterol + 6 reduced adrenodoxin + 3 O2	-	
1.14.15.6	cholesterol + 6 reduced adrenodoxin + 3 O2	first step in biosynthesis of all steroid hormones	
1.14.15.6	cholesterol + 6 reduced adrenodoxin + 3 O2	overall reaction	
1.14.15.6	cholesterol + reduced adrenal ferredoxin + O2	-	
1.14.15.6	cholesterol + reduced adrenal ferredoxin + O2	first and rate-limiting enzyme in adrenal steroidogenesis	
1.14.15.6	cholesterol + reduced ferredoxin + O2	metabolic regulation of enzyme expression, overview	
1.14.15.6	cholesterol + reduced ferredoxin + O2	the catalyzed reaction is not the rate-limiting step in steroidogenesis except in placenta which lacks the steroidogenic acute regulatory protein, overview, enzyme deficiency by mutations leads to severe disorders, overview	
1.14.15.6	additional information	involved in control of pain mechanisms	
1.14.15.6	additional information	leptin interferes with adrenocorticotropin/cAMP signaling, possibly through a janus kinase 2-phosphatidylinositol 3-kinase/akt-phosphodiesterase 3-cAMP pathway, to down-regulate cholesterol side-chain cleavage cytochrome P450 enzyme in human adrenocortical NCI-H295 cell line, mechanism, overview	
1.14.15.6	additional information	the enzyme is a key enzyme in brain steroidogenesis	
1.14.15.6	additional information	the enzyme is important in steroidogenesis, regulatory mechanism, overview	
1.14.15.6	additional information	cytochrome P450scc metabolizes vitamin D3 to 20-hydroxyvitamin D3 and 20,23-dihydroxyvitamin D3, as well as 1-hydroxyvitamin D3 to 1alpha,20-dihydroxyvitamin D3. It also cleaves the side chain of 7-dehydrocholesterol producing 7-dehydropregnenolone, which can be transformed to 20-hydroxy-7-dehydropregnenolone