1.13.11.34 (5S,6E,8Z,11Z,14Z)-5-hydroperoxyicosa-6,8,11,14-tetraenoate epoxidation 1.13.11.34 (5Z,8Z,10E,12S,14Z)-12-hydroxyicosa-5,8,10,14-tetraenoic acid + O2 - 1.13.11.34 (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate - 1.13.11.34 (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate efficient LTA4 formation of 5LO requires both phosphatidyl choline and coactosin-like protein 1.13.11.34 5-hydroperoxyeicosatetraenoic acid - 1.13.11.34 arachidonate + O2 - 1.13.11.34 arachidonate + O2 hydroperoxidation 1.13.11.34 arachidonate + O2 overall reaction 1.13.11.34 arachidonic acid + O2 - 1.13.11.34 arachidonic acid + O2 first committed step in the synthesis of leukotrienes 1.13.11.34 additional information the enzyme is involved in lipoxin synthesis from 5,15-dihydroxyperoxyeicosatetraenoic acid via 5,6-epoxide 1.13.11.34 additional information enzyme of leukotriene biosynthetic pathway 1.13.11.34 additional information key enzyme in leukotriene metabolism, in human mast cells glucocorticoids effectively and selectively upregulate the expression 1.13.11.34 additional information key enzyme in leukotriene biosynthesis, catalyzes the initial steps in the conversion of arachidonic acid to biologically active leukotrienes. Leukotrienes are considered as potent mediators of inflammatory and allergic reactions 1.13.11.34 additional information key enzyme in the biosynthesis of proinflammatory leukotrienes 1.13.11.34 additional information 5-lipoxygenase/cyclooxygenase-2 cross-talk through cysteinyl leukotriene receptor 2 in endothelial cells, overview 1.13.11.34 additional information 5-LO inhibition in obese mice downregulates genes involved in hepatic fatty acid uptake, i.e. L-FABP and FAT/CD36, and normalizes PPARalpha and acyl-CoA oxidase expression, whereas the expression of lipogenic genes, i.e. FASN and SREBP-1c, remains unaltered. The 5-LO inhibition restores hepatic microsomal triglyceride transfer protein, MTP, activity in parallel with a stimulation of hepatic VLDL-TG and ApoB secretion in obese mice, overview 1.13.11.34 additional information 5-LOX is the key enzyme in the biosynthesis of leukotrienes through catalyzing the initial two steps in conversion of arachidonic acid to leukotrienes 1.13.11.34 additional information ALOX5-derived lipid mediators leukotrienes and lipoxins have regulatory functions in inflammation by modulating activities of immune cells and cytokine production, host control of Mycobacterium tuberculosis is regulated by 5-lipoxygenase 1.13.11.34 additional information inhibition of 5-lipoxygenase does not affect cardiac ischemia-reperfusion injury but the post-ischemic inflammatory response, overview 1.13.11.34 additional information inhibition of COX pathways does not increase the transformation of arachidonic acid by the 5-LOX pathway 1.13.11.34 additional information key enzyme in biosynthesis of leukotrienes, overview. Upon cell activation, cytosolic and nuclear enzyme translocates the nuclear envelope, where it interacts with phospholipase A2, making free arachidonate available for 5-LO, and with 5-LO activating protein, i.e. FLAP. 5-LO regulates cancer cell survival and interferes with the mechanismtumor suppression, and increases cancer cell chemoresistance, overview 1.13.11.34 additional information key enzyme in the leukotriene biosynthesis, pathway overview, regulatory mechanisms underlying the expression and control of 5-LO activity, overview 1.13.11.34 additional information key enzyme in the leukotriene biosynthesis, pathway overview, the 5-LO pathway is linked to the development of cardiovascular disease and other diseases, regulatory mechanisms underlying the expression and control of 5-LO activity, overview 1.13.11.34 additional information no significant effect of LTB4, 12-hydroperoxyeicosatetraenoic acid or 15-hydroperoxyeicosatetraenoic acid on leukemic blast growth and on their apoptose rate, overview 1.13.11.34 additional information the enzyme is involved in survival of Epstein-Barr virus-converted B lymphoma cells via function of 5-hydroperoxyeicosatetraenoic acid, overview 1.13.11.34 additional information the enzyme is the key enzyme in biosynthesis of biologically active leukotrienes 1.13.11.34 additional information the enzyme, catalyzing the key step in leukotriene biosynthesis, interacts with methyl jasmonate, which is probably involved in the anticarcinogenic activity of methyl jasmonate inducing apoptosis, overview 1.13.11.34 additional information the enzyme catalyzes the dioxygenation of polyunsaturated fatty acids