3.4.22.49	Ca2+	Ca2+-levels affect separase function, C-terminal region contains a Ca2+-binding motif	638862	
3.4.22.49	Ca2+	the enzyme contains a Ca2+-binding EF-hand motif, which can possibly affect separase interaction with the spindle, similar to the budding yeast Esp1, or alternatively Ca2+ might be a critical component for (auto-)catalysis	718194