1.2.3.15 copper protein contains a radical-coupled copper complex, a mononuclear Cu(II) center with an axial coordination 762882 1.2.3.15 Cu2+ 0.7-0.8 equivalents of Cu2+ per mol enzyme 738564 1.2.3.15 Cu2+ enzyme is a copper radical oxidase. Residues comprising the copper coordinating active site and the radical redox site are Cys228, Tyr272, Tyr495, His496, and His581 763112 1.2.3.15 Cu2+ full activation takes more than 1 h with 1 mM CuSO4 at pH 6.0 739561 1.2.3.15 additional information no activation is observed with Mg2+, Zn2+, Fe2+, or Mn2+ 739561