1.14.11.26 Fe2+ acts as cofactor, the iron-binding centre in this family of enzymes essentially provides versatility and flexibility in catalysing a variety of oxidative reactions that include desaturation, ring expansion, and hydroxylation 699366 1.14.11.26 Fe2+ dependent on, required for catalysis 744105 1.14.11.26 Fe2+ essential fpr DAOC hydrolase activity, enzyme is a nonheme Fe2+ oxygenase 700004 1.14.11.26 Fe2+ Fe2+-dependent 671443 1.14.11.26 Fe2+ required 725639 1.14.11.26 Fe2+ required for both activities 661974 1.14.11.26 Fe2+ required, Ka-value 0.008 mM 440380 1.14.11.26 Fe2+ required, without Fe2+, less than 2% of maximum activity 662088 1.14.11.26 additional information Fe2+ cannot be replaced by Mg2+, Mn2+, Ca2+, Co2+, Cu2+, Ni2+ or Zn2+ 661974, 662088