3.4.22.26	Ca2+	-	30159	
3.4.22.26	Ca2+	below 1 mM Mn2+, additive effect in the presence of Mn2+	30161	
3.4.22.26	Ca2+	dependent on	667302	
3.4.22.26	Ca2+	immunoimmobilized enzyme does not require Ca2+	30161	
3.4.22.26	Ca2+	required for activity, activates	755327	
3.4.22.26	Ca2+	requirement, 7 mM	30160	
3.4.22.26	Cd2+	1 mM: increase of activity by factor 1.7	710603	
3.4.22.26	Mg2+	10 mM	30160	
3.4.22.26	Mg2+	5 mM	30161	
3.4.22.26	Mg2+	activates	667302	
3.4.22.26	Mg2+	no additive effect of Ca2+ and Mg2+, immunoimmobilized enzyme does not require Mg2+	30161	
3.4.22.26	Mg2+	requirement, can replace Ca2+	30160, 30161	
3.4.22.26	Mn2+	1 mM: increase of activity by factor 3.5	710603	
3.4.22.26	Mn2+	activates	679297	
3.4.22.26	Mn2+	below 1 mM, additive effect in the presence of Ca2+	30161	
3.4.22.26	Mn2+	but different binding site than Ca2+ (or Mg2+), 0.02 mM	30160	
3.4.22.26	Mn2+	immunoimmobilized enzyme does not require Mn2+	30161	
3.4.22.26	Mn2+	inhibits above 1 mM	30161	
3.4.22.26	Mn2+	requirement, can replace Ca2+	30160, 30161	
3.4.22.26	additional information	binding cancer procoagulant to a surface changes its divalent ion requirements	30160, 30161	
3.4.22.26	additional information	divalent metal ions are responsible for correct conformation of the enzyme, enzyme contains 2 metal binding sites: 1 for Ca2+ and Mg2+ binding, and 1 for Mn2+ and Cd2+ binding	651435	
3.4.22.26	additional information	no activation by Fe2+ or Zn2+ in the absence of Ca2+	30161