3.2.2.8	Ca2+	dependent on	
3.2.2.8	Ca2+	required in maintaining the active site structure	
3.2.2.8	Ca2+	the substrate binds to the Ca2+-containing active site in the catalytic cavity at the C-terminal end of the core beta-sheet	
3.2.2.8	Na+	likely bound to the enzyme under physiological conditions