1.1.99.28 membrane translocated across the membrane in fully folded form. A twin-arginine motif in the signal peptide directs it to a Sec-independent pathway by which it is translocated, in fully folded form, into the periplasm where it functions to produce sorbitol for osmoprotection 16020 654586 1.1.99.28 periplasm - - -, 10906, 10907, 10910, 10913, 10915, 655145, 656483, 711819, 723903, 724200, 724873, 725640, 762807 1.1.99.28 periplasm the efficient export of NADP-containing glucose-fructose oxidoreductase to the periplasm of Zymomonas mobilis depends both on an intact twin-arginine motif in the signal peptide and on the generation of a structural export signal induced by cofactor binding - 655405