1.1.1.1 alcohol dehydrogenase mitochondrion - 5739 721749 1.1.1.1 alcohol dehydrogenase mitochondrion higher enzyme level in mitochondria from cells grown at pH 6.0 than in mitochondria from cells grown at pH 3.7 5739 739328 1.1.1.1 alcohol dehydrogenase mitochondrion HpADH3 5739 -, 721388 1.1.1.1 alcohol dehydrogenase mitochondrion KlDH3 and KlADH4 are genes encoding mitochondrial alcohol dehydrogenase activities located within the mitochondria. Ethanol induces the transcription of KlADH4 and, conversely, represses that of KlADH3 5739 668675 1.1.1.1 alcohol dehydrogenase mitochondrion KmAdh3 possesses an amino-terminal extension as a mitochondrial targeting sequence 5739 -, 685652 1.1.1.1 alcohol dehydrogenase mitochondrion KmAdh4 possesses an amino-terminal extension as a mitochondrial targeting sequence 5739 -, 685652 1.1.1.100 3-oxoacyl-[acyl-carrier-protein] reductase mitochondrion - 5739 704721, 740558 1.1.1.103 L-threonine 3-dehydrogenase mitochondrion - 5739 737579, 738933 1.1.1.105 all-trans-retinol dehydrogenase (NAD+) mitochondrion - 5739 656260 1.1.1.145 3beta-hydroxy-DELTA5-steroid dehydrogenase mitochondrion - 5739 389385, 389391, 389399, 389401, 740914, 762899, 763756 1.1.1.145 3beta-hydroxy-DELTA5-steroid dehydrogenase mitochondrion inner mitochondrial membrane 5739 389399 1.1.1.145 3beta-hydroxy-DELTA5-steroid dehydrogenase mitochondrion isoform 3betaHSD2 associates with the inner mitochondrial membrane or outer mitochondrial membrane translocases facing the intermembrane space. Tthis interaction promotes the conformational change needed for full activity. 3betaHSD2 associates with the inner mitochondrial membrane but does not integrate into the membrane. 3betaHSD2 forms a transient association with the translocases Tim50 and Tom22 and with Tim23. This association occurs primarily through the interaction of Tim50 with the N-terminus of 3betaHSD2 and contributes to enzymatic activity. Tim50 knockdown inhibits catalysis of dehydroepiandrostenedione to androstenedione and pregnenolone to progesterone. Although Tim50 knockdown decreases 3betaHSD2 expression, restoration of expression via proteasome and protease inhibition does not rescue activity 5739 725447 1.1.1.150 21-hydroxysteroid dehydrogenase (NAD+) mitochondrion isoform RDH13 5739 688677 1.1.1.178 3-hydroxy-2-methylbutyryl-CoA dehydrogenase mitochondrion - 5739 673530, 711851 1.1.1.2 alcohol dehydrogenase (NADP+) mitochondrion - 5739 286177, 286204, 286214, 654908 1.1.1.211 long-chain-3-hydroxyacyl-CoA dehydrogenase mitochondrion - 5739 -, 288681, 686162, 688119, 723341, 740102, 740106, 740438, 740557, 740641, 741457 1.1.1.237 hydroxyphenylpyruvate reductase mitochondrion - 5739 657023 1.1.1.27 L-lactate dehydrogenase mitochondrion - 5739 689715, 762363 1.1.1.27 L-lactate dehydrogenase mitochondrion inner compartment, transport and metabolism of L-lactate, overview 5739 685322 1.1.1.27 L-lactate dehydrogenase mitochondrion L-lactate dehydrogenase is restricted to the inner mitochondrial compartments 5739 747163 1.1.1.27 L-lactate dehydrogenase mitochondrion LDH is present in the inner mitochondrial compartments 5739 686648 1.1.1.27 L-lactate dehydrogenase mitochondrion LDH-A 5739 -, 685502 1.1.1.27 L-lactate dehydrogenase mitochondrion mL-LDH is restricted in inner compartment 5739 746989 1.1.1.277 3beta-hydroxy-5beta-steroid dehydrogenase mitochondrion - 5739 -, 389563 1.1.1.28 D-lactate dehydrogenase mitochondrion - 5739 -, 760993 1.1.1.28 D-lactate dehydrogenase mitochondrion D-lactate dehydrogenase is inserted into the inner membrane of mitochondria through its transmembrane domain located close to the N-terminus of the polypeptide chain in such a way that the protein globule is exposed in the intermembrane space 5739 667751 1.1.1.284 S-(hydroxymethyl)glutathione dehydrogenase mitochondrion - 5739 -, 724453, 762615, 762616, 762890, 763054 1.1.1.284 S-(hydroxymethyl)glutathione dehydrogenase mitochondrion presence of S-nitrosoglutathione, S-nitrosoglutathione reductase and nitrated proteins 5739 723896 1.1.1.284 S-(hydroxymethyl)glutathione dehydrogenase mitochondrion the enzyme contains a mitochondrial targeting peptide 5739 763605 1.1.1.30 3-hydroxybutyrate dehydrogenase mitochondrion - 5739 286514, 286515, 286516, 286517, 286518, 286519, 286521, 286522, 286525, 286527, 286528, 286529, 286530, 286535, 286542, 655126, 655261, 689351 1.1.1.30 3-hydroxybutyrate dehydrogenase mitochondrion beta-hydroxybutyrate dehydrogenase from heavy and light mitochondria are isoforms 5739 668322 1.1.1.30 3-hydroxybutyrate dehydrogenase mitochondrion light and heavy mitochondria, enzyme expression and activity is increased in heavy mitochondria in hibernating state, overview 5739 685409 1.1.1.30 3-hydroxybutyrate dehydrogenase mitochondrion located on the matrix face of the inner membrane 5739 286512, 286513, 286533, 286538 1.1.1.300 NADP-retinol dehydrogenase mitochondrion isoform RDH13 5739 688677 1.1.1.31 3-hydroxyisobutyrate dehydrogenase mitochondrion - 5739 688515, 722472 1.1.1.34 hydroxymethylglutaryl-CoA reductase (NADPH) mitochondrion - 5739 286557, 286560, 286564 1.1.1.34 hydroxymethylglutaryl-CoA reductase (NADPH) mitochondrion isozyme Hmg1 5739 686736 1.1.1.35 3-hydroxyacyl-CoA dehydrogenase mitochondrion - 5739 -, 286269, 286588, 286589, 286590, 286591, 286601, 286606, 286607, 286612, 33713, 657049, 657276, 673340, 673530, 684902, 685573, 687573, 690046, 723558 1.1.1.35 3-hydroxyacyl-CoA dehydrogenase mitochondrion matrix enzyme 5739 286603 1.1.1.36 acetoacetyl-CoA reductase mitochondrion isozyme AKR1B15.1 5739 740743 1.1.1.37 malate dehydrogenase mitochondrion - 5739 -, 286626, 286627, 286628, 286629, 286630, 286632, 286636, 286637, 286638, 286640, 286641, 286644, 286645, 286646, 286647, 286649, 286652, 286654, 286655, 286656, 286661, 286662, 286663, 286664, 286665, 286669, 286672, 286676, 655486, 656579, 656753, 656883, 656929, 669002, 670193, 679243, 689325, 696067, 700068, 700338, 700824, 721236, 740165, 760668, 760678 1.1.1.37 malate dehydrogenase mitochondrion highly expressed mMDH1 and lower expressed mMDH2 isoforms 5739 713318 1.1.1.37 malate dehydrogenase mitochondrion inner or outer membrane, m-MDH located in the inner membrane matrix 5739 286629 1.1.1.37 malate dehydrogenase mitochondrion isozyme mMDH 5739 711909, 712850 1.1.1.37 malate dehydrogenase mitochondrion Mdh1, matrix 5739 686953 1.1.1.37 malate dehydrogenase mitochondrion Mdh2 5739 723540 1.1.1.37 malate dehydrogenase mitochondrion mitochondrial isozyme 5739 688101 1.1.1.37 malate dehydrogenase mitochondrion mitochondrial MDH 5739 -, 711519 1.1.1.37 malate dehydrogenase mitochondrion outer membrane, intermembrane space, inner membrane, matrix 5739 -, 286653, 286672 1.1.1.38 malate dehydrogenase (oxaloacetate-decarboxylating) mitochondrion - 5739 286678, 286681, 286691, 286693, 286698, 656983, 685215, 695884, 741010, 760840 1.1.1.39 malate dehydrogenase (decarboxylating) mitochondrion - 5739 286704, 286708, 286715, 654651, 654720, 656163, 656983, 657321, 657362, 685215, 685622, 689604, 712417, 723540, 738272, 741121, 761183, 761186, 762109 1.1.1.39 malate dehydrogenase (decarboxylating) mitochondrion 65% of the activity 5739 286712 1.1.1.39 malate dehydrogenase (decarboxylating) mitochondrion isozyme ME2 5739 687568 1.1.1.39 malate dehydrogenase (decarboxylating) mitochondrion isozyme NAD-ME1 5739 711147 1.1.1.39 malate dehydrogenase (decarboxylating) mitochondrion isozymes ME2 and ME3 5739 712942 1.1.1.39 malate dehydrogenase (decarboxylating) mitochondrion isozymes NAD-ME1 and NAD-ME2 5739 711147 1.1.1.39 malate dehydrogenase (decarboxylating) mitochondrion ME2 5739 713373 1.1.1.39 malate dehydrogenase (decarboxylating) mitochondrion one of NAD-ME isoforms with MW 110 kDa is located in mitochondria of bundle sheath cells of control and drought-exposed plants, and another isoform of MW 121 kDa is formed in mitochondria of bundle sheath cells under influence of drought. After resuming watering the 121 kDa isoform disappears again. About 90.6% of the total NAD-ME activity is localized in mitochondrial stroma of bundle sheath cells 5739 741191 1.1.1.39 malate dehydrogenase (decarboxylating) mitochondrion predominantly in the matrix space 5739 286712 1.1.1.40 malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) mitochondrion - 5739 286715, 286734, 286735, 286738, 728207, 739163, 741010, 761074, 761183, 761332 1.1.1.40 malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) mitochondrion 2 distinct enzyme forms are present in cytosol and in mitochondria 5739 286725 1.1.1.40 malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) mitochondrion both cytosolic and mitochondrial isozymes are more abundant in the insect stage, although they can be immunodetected in the bloodstream forms 5739 -, 712042 1.1.1.40 malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) mitochondrion expression of the mitochondrial ME is upregulated in amastigotes 5739 -, 712042 1.1.1.40 malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) mitochondrion isozyme ME3 5739 687568 1.1.1.40 malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) mitochondrion mitochondrial isozyme, appears to be clearly more abundant in the insect stage, although it can be immunodetected in the bloodstream form 5739 -, 712042 1.1.1.40 malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) mitochondrion mitochondrial isozyme, the expression of the mitochondrial isozyme seems to be clearly upregulated in amastigotes 5739 -, 712042 1.1.1.40 malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) mitochondrion mitochondrial malic enzyme ME3 5739 712942 1.1.1.41 isocitrate dehydrogenase (NAD+) mitochondrion - 5739 -, 286749, 286754, 286761, 286762, 286766, 286767, 286774, 654652, 654843, 656118, 657111, 667647, 670544, 670547, 684713, 685719, 712440, 713076, 721381, 740114, 741407, 741458, 760834, 762407 1.1.1.41 isocitrate dehydrogenase (NAD+) mitochondrion exclusively 5739 654914 1.1.1.41 isocitrate dehydrogenase (NAD+) mitochondrion resticted to 5739 740425 1.1.1.42 isocitrate dehydrogenase (NADP+) mitochondrion - 5739 -, 286782, 286783, 286785, 286792, 286793, 654341, 654649, 654652, 655456, 655663, 656093, 656180, 668697, 669307, 669373, 670236, 670334, 686864, 686899, 689917, 696487, 711119, 739984, 740117, 740583, 760832, 761047, 762409, 762446 1.1.1.42 isocitrate dehydrogenase (NADP+) mitochondrion IDH2 5739 712614, 713508 1.1.1.42 isocitrate dehydrogenase (NADP+) mitochondrion IDH2 and IDH3 5739 713508 1.1.1.42 isocitrate dehydrogenase (NADP+) mitochondrion IDP1 5739 -, 711006 1.1.1.42 isocitrate dehydrogenase (NADP+) mitochondrion IDPm 5739 712077 1.1.1.42 isocitrate dehydrogenase (NADP+) mitochondrion increase in enzyme activity during ischemia, enzyme from ischemic heart mitochondria demonstrates higher activation energy and lower thermal stability and differs in KM-value and regulation 5739 670236 1.1.1.42 isocitrate dehydrogenase (NADP+) mitochondrion isoenzyme IDP1 5739 684709 1.1.1.42 isocitrate dehydrogenase (NADP+) mitochondrion isozyme ICD1, mainly 5739 656431 1.1.1.42 isocitrate dehydrogenase (NADP+) mitochondrion isozyme IDP1 5739 654367, 656233 1.1.1.42 isocitrate dehydrogenase (NADP+) mitochondrion isozyme mICDH 5739 656588 1.1.1.42 isocitrate dehydrogenase (NADP+) mitochondrion light-inducible isozyme 5739 654843 1.1.1.42 isocitrate dehydrogenase (NADP+) mitochondrion mitochondrial NADP+-dependent isocitrate dehydrogenase 5739 711330 1.1.1.42 isocitrate dehydrogenase (NADP+) mitochondrion mitochondrial targeting peptide signal is predicted for IDH1 5739 723129 1.1.1.49 glucose-6-phosphate dehydrogenase (NADP+) mitochondrion - 5739 287017 1.1.1.51 3(or 17)beta-hydroxysteroid dehydrogenase mitochondrion - 5739 287077, 677079 1.1.1.59 3-hydroxypropionate dehydrogenase mitochondrion - 5739 738640 1.1.1.62 17beta-estradiol 17-dehydrogenase mitochondrion - 5739 760700, 761037 1.1.1.62 17beta-estradiol 17-dehydrogenase mitochondrion isozyme 17beta-HSD10 5739 675983 1.1.1.62 17beta-estradiol 17-dehydrogenase mitochondrion isozyme AKR1B15.1 5739 740743 1.1.1.75 (R)-aminopropanol dehydrogenase mitochondrion - 5739 287300, 287301, 287307 1.1.1.79 glyoxylate reductase (NADP+) mitochondrion - 5739 286409, 287327, 761190 1.1.1.79 glyoxylate reductase (NADP+) mitochondrion intermembrane space and inner membrane 5739 287321 1.1.1.79 glyoxylate reductase (NADP+) mitochondrion isoform GLYR2 5739 761177 1.1.1.8 glycerol-3-phosphate dehydrogenase (NAD+) mitochondrion - 5739 667415, 712122 1.1.1.8 glycerol-3-phosphate dehydrogenase (NAD+) mitochondrion determined by isopycnic gradient centrifugation 5739 287358 1.1.1.8 glycerol-3-phosphate dehydrogenase (NAD+) mitochondrion isoform Gpd2p, contains mitochondrial presequence sufficient for targeting 5739 656246 1.1.1.8 glycerol-3-phosphate dehydrogenase (NAD+) mitochondrion localisation shown in Saccharomyces cerevisiae via GFP-fusion proteins 5739 675870 1.1.1.8 glycerol-3-phosphate dehydrogenase (NAD+) mitochondrion predicted from sequence 5739 675870 1.1.1.8 glycerol-3-phosphate dehydrogenase (NAD+) mitochondrion sn-glycerol 3-phosphate dehydrogenase generates superoxide about equally to each side of the membrane 5739 667785 1.1.1.80 isopropanol dehydrogenase (NADP+) mitochondrion - 5739 287362