3.4.23.39 food vacuole - 20020 669157 3.4.23.39 membrane proplasmepsin II is a type II integral membrane protein that is transported though the secretory pathway before cleavage to the soluble form 16020 648184 3.4.23.39 vacuole - 5773 648180, 648184, 753556 3.4.23.39 vacuole digestive vacuole 5773 -, 648194 3.4.23.39 vacuole food vacuole 5773 648204, 648208 3.4.23.39 vacuole pro-plasmepsin II is transported through the secretory system to cytostomal vacuoles and then is carried along with its substrate hemoglobin to the food vacuole where it is proteolytically processed to mature PMII 5773 669571 3.4.23.39 vacuole the plasmepsins, although not essential, contribute significantly to the fitness of the parasite and are required for efficient degradation of endosomal vesicles delivered to the digestive vacuole 5773 682004