3.4.22.49	centrosome	-	5813	731689, 732669, 732703	
3.4.22.49	centrosome	localized in centrosomes before anaphase	5813	638869	
3.4.22.49	chromosome	-	5694	697240, 731697	
3.4.22.49	chromosome	the spatial localization of separase varies with the progression of the cell cycle. In interphase cells, separase is localized in the cytoplasm, but during mitosis it accumulates in the nucleus and associates with chromosomes	5694	752903	
3.4.22.49	cytoplasm	Cut1 seems to be localized in the cytoplasm	5737	638856	
3.4.22.49	cytoplasm	in nondividing cells in healthy tissue, immunofluorescence microscopy	5737	697382	
3.4.22.49	cytoplasm	prodominant localisation	5737	700280	
3.4.22.49	cytoplasm	separase is abundantly expressed within the cytoplasm of a broad range of human tumor cell lines, including MDA-MB-231 breast carcinoma cells	5737	718433	
3.4.22.49	cytoplasm	the spatial localization of separase varies with the progression of the cell cycle. In interphase cells, separase is localized in the cytoplasm, but during mitosis it accumulates in the nucleus and associates with chromosomes	5737	752903	
3.4.22.49	membrane	-	16020	718433	
3.4.22.49	additional information	budding yeast Esp1 is localized to the centrosomes and spindle before anaphase	-	718194	
3.4.22.49	additional information	human separase is associated with centrosomes but not with spindle before anaphase, featuring predominantly cytoplasmic localization in non-dividing cells	-	718194	
3.4.22.49	additional information	in fission yeast Cut1 features similar localization in the beginning of anaphase onset persisting on the spindle until mid-anaphase	-	718194	
3.4.22.49	additional information	separase binds terminin proteins and HP1, and that it is enriched at telomeres	-	754836	
3.4.22.49	additional information	Separase is present in the cell during the entire cell cycle, but excluded from the nucleus until the metaphase-anaphase transition	-	700280	
3.4.22.49	additional information	separase localizes to cortically located filamentous structures in prometaphase I upon oocyte maturation. After fertilization, separase disappears from these structures and appears on cortical granules by anaphase I	-	679433	
3.4.22.49	nucleus	-	5634	638856	
3.4.22.49	nucleus	possibly localized in the nucleus, in the mitotic stage Cut1 is mobilized to the spindle poles and the spindle microtubules	5634	638856	
3.4.22.49	nucleus	the spatial localization of separase varies with the progression of the cell cycle. In interphase cells, separase is localized in the cytoplasm, but during mitosis it accumulates in the nucleus and associates with chromosomes	5634	752903	
3.4.22.49	nucleus	tumor cells significantly more abundant, immunofluorescence microscopy	5634	697382	
3.4.22.49	nucleus	while inhibiting separase, securin is able to promote nuclear accumulation of separase	5634	638864