6.3.3.6 (3S,5S)-carbapenam 3-carboxylate - 15347 6.3.3.6 AMP uncompetitive inhibition versus both substrates 30 6.3.3.6 diphosphate the competitive inhibition exhibited by diphosphate versus ATP allows the assignment of diphosphate as the last product released 17 6.3.3.6 L-proline the uncompetitive nature of the inhibition of the dead-end inhibitor, L-proline, versus ATP is consistent with a mechanism with ordered substrate binding where ATP binds first followed by (2S,5S)-carboxymethylproline 243