2.4.99.20 Cu2+ - 19 2.4.99.20 additional information the cyclization reaction is insensitive to free Ca2+ concentration in the range 20 nM–100 microM. Mg2+ is not inhibitory 2 2.4.99.20 NAD+ - 7 2.4.99.20 NADP+ - 10 2.4.99.20 nicotinamide inhibition of the cyclization reaction and is 30fold more potent at suppressing the base-exchange reaction. Inhibition is not via a competition with the nicotinic acid-binding site 267 2.4.99.20 Zn2+ - 14