2.3.1.191	(3R)-3-hydroxylauroyl-methylphosphopantetheine	competitive inhibitor with respect to UDP-3-O-((3R)-3-hydroxymyristoyl)-alpha-D-glucosamine and an uncompetitive inhibitor with respect to (3R)-3-hydroxymyristoyl-[acyl-carrier protein]	26623	
2.3.1.191	(3R)-3-hydroxylauroylmethylphosphopantetheine	uncompetitive inhibitor against (3R)-3-hydroxymyristoyl-[acyl-carrier protein] and a competitive inhibitor against UDP-3-O-((3R)-3-hydroxymyristoyl)-alpha-D-glucosamine	151290	
2.3.1.191	(3R)-3-hydroxymyristoyl-[acyl-carrier protein]	-	2623	
2.3.1.191	4-(2-chlorophenyl)-3-hydroxy-7,7-dimethyl-2-phenyl-7,8-dihydro-2H-pyrazolo[3,4-b]quinolin-5(6H)-one	-	247250	
2.3.1.191	acyl-carrier protein	competitive inhibitor with respect to (3R)-3-hydroxymyristoyl-[acyl-carrier protein] and a noncompetitive inhibitor with respect to UDP-3-O-((3R)-3-hydroxymyristoyl)-alpha-D-glucosamine	1134	
2.3.1.191	Ca2+	inhibition is overcome by the addition of excess (3R)-3-hydroxymyristoyl-[acyl-carrier protein]	15	
2.3.1.191	Mg2+	-	6	
2.3.1.191	additional information	divalent cations inhibit (3R)-3-hydroxymyristoyl-[acyl-carrier protein]-dependent acylation but not (3R)-3-hydroxylauroylmethylphosphopantetheine-dependent acylation, indicating that the acidic recognition helix of (3R)-3-hydroxymyristoyl-[acyl-carrier protein] contributes to binding; Na+ and K+ ions do not inhibit LpxD activity	2	
2.3.1.191	RJPXD33	i.e. TNLYMLPKWDIP, peptide inhibitor, binds to both UDP-N-acetylglucosamine acyltransferase (LpxA, EC 2.3.1.129) and UDP-3-O-(acyl)-glucosamine acyltransferase. Comparison with binding to LpxA suggests overlap with the acyl-phosphopantetheine arm of acyl-ACP, thereby inhibiting acyl-ACP from binding to LpxD. RJPXD33 binds to LpxD without the prior binding of other ligands	87732	
2.3.1.191	TNLYMLPKWDIP-NH2	i.e. peptide RJPXD33	247251