1.14.14.29	3alpha-adiol	-	21786	
1.14.14.29	5alpha-androstane-3alpha,17beta-diol	inhibition of the reaction with dehydroepiandrosterone	2012	
1.14.14.29	5alpha-androstane-3alpha,17beta-diol	inhibition of the reaction with dehydroepiandrosterone; significantly inhibits CYP7B1-mediated 7alpha-hydroxylation	2012	
1.14.14.29	5alpha-Androstane-3beta,17beta-diol	inhibits hydroxylation of dehydroepiandrosterone by approximately 60-70% when both steroids are present at equimolar concentrations. A 10fold higher concentration of 5alpha-androstane-3beta,17beta-diol than of dehydroepiandrosterone in the incubation mixture results in the suppression of dehydroepiandrosterone hydroxylation by 80%. In HEK293 cells, the suppressive effect of 5alpha-androstane-3beta,17beta-diol on dehydroepiandrosterone metabolism is statistically significant also at a 10fold lower concentration of 5alpha-androstane-3beta,17beta-diol than of dehydroepiandrosterone in the incubation mixture	3060	
1.14.14.29	5alpha-Androstane-3beta,17beta-diol	inhibits hydroxylation of dehydroepiandrosterone by approximately 60-70% when both steroids are present at equimolar concentrations. A 10fold higher concentration of 5alpha-androstane-3beta,17beta-diol than of dehydroepiandrosterone in the incubation mixture results in the suppression of dehydroepiandrosterone hydroxylation by 80%	3060	
1.14.14.29	dehydroepiandrosterone	inhibits hydroxylation of 5alpha-androstane-3beta,17beta-diol	275	
1.14.14.29	LY294002	specific inhibitor of phosphatidylinositol 3-kinase, abolishes estrogen receptor-mediated upregulation of a CYP7B1 promoter-luciferase reporter in Hep-G2 cells but not in HEK-293 cells	770	
1.14.14.29	additional information	no inhibition: testosterone, dehydroepiandrosterone sulfate	2	
1.14.14.29	additional information	testosterone, dehydroepiandrosterone-sulfate or 22-hydroxycholesterol have little or no effects on CYP7B1-mediated activities	2	
1.14.14.29	additional information	mRNA encoding CYP39A1 gene is significantly repressed by pregnane X receptor activation in primary hepatocytes of wild-type mice but not in pregnane X receptor-/- hepatocytes	2