3.6.5.4 GDP - 3.6.5.4 LamB signal peptide dose-dependent inhibition of GTPase activity 3.6.5.4 additional information membrane association of FtsY is stabilized by blocking its GTPase activity 3.6.5.4 signal peptide isolated functional signal peptides bind nonspecifically to the RNA component of SRP and aggregate the entire signal recognition particle, leading to a loss of its intrinsic GTPase activity, this effect is an artifact of the high peptide concentrations and low salt conditions used in in vitro studies, signal sequences at the N-terminus of nascent chains in vivo do not exhibit this activity