2.7.11.26 (2'Z,3'E)-6-bromoindirubin-3'-oxime - 77847 2.7.11.26 (2S)-3-cyclohexyl-2-(9H-purin-6-ylamino)propan-1-ol ZINC00012956 254430 2.7.11.26 (4-amino-2-((4-chlorophenyl)amino)thiazol-5-yl)(3-nitrophenyl)methanone enzyme binding structure analysis 217784 2.7.11.26 (5,6-dibromo-1H-indol-3-yl)methanol - 254544 2.7.11.26 (5,6-dichloro-1H-indol-3-yl)methanol - 254545 2.7.11.26 (5,6-difluoro-1H-indol-3-yl)methanol - 254546 2.7.11.26 (5-bromo-6-chloro-1H-indol-3-yl)methanol - 254548 2.7.11.26 (5-bromo-6-fluoro-1H-indol-3-yl)methanol - 254549 2.7.11.26 (6-bromo-5-chloro-1H-indol-3-yl)methanol - 254590 2.7.11.26 (6-bromo-5-fluoro-1H-indol-3-yl)methanol - 254591 2.7.11.26 (Rp)-adenosine 3',5'-cyclic monophosphorothionate triethyl ammonium salt inhibitor of PKA 57765 2.7.11.26 1-(4-methoxyphenyl)-6-(5-[[3-(trifluoromethyl)benzyl]sulfanyl]-1,3,4-oxadiazol-2-yl)-1H-benzimidazole - 77890 2.7.11.26 1-(4-methoxyphenyl)-6-(5-[[4-methoxy-3-(trifluoromethyl)benzyl]sulfanyl]-1,3,4-oxadiazol-2-yl)-1H-benzimidazole - 77889 2.7.11.26 1-(5,6-dibromo-1H-indol-3-yl)methanamine - 254809 2.7.11.26 1-(5,6-dibromo-1H-indol-3-yl)propan-2-one - 254810 2.7.11.26 1-(5,6-dichloro-1H-indol-3-yl)methanamine - 254811 2.7.11.26 1-(5,6-dichloro-1H-indol-3-yl)propan-2-one - 254812 2.7.11.26 1-(5,6-difluoro-1H-indol-3-yl)methanamine - 254813 2.7.11.26 1-(5,6-difluoro-1H-indol-3-yl)propan-2-one - 254814 2.7.11.26 1-(5-bromo-6-chloro-1H-indol-3-yl)methanamine - 254815 2.7.11.26 1-(5-bromo-6-chloro-1H-indol-3-yl)propan-2-one - 254816 2.7.11.26 1-(5-bromo-6-fluoro-1H-indol-3-yl)methanamine - 254817 2.7.11.26 1-(5-bromo-6-fluoro-1H-indol-3-yl)propan-2-one - 254818 2.7.11.26 1-(6-bromo-5-chloro-1H-indol-3-yl)methanamine - 254822 2.7.11.26 1-(6-bromo-5-chloro-1H-indol-3-yl)propan-2-one - 254823 2.7.11.26 1-(6-bromo-5-fluoro-1H-indol-3-yl)methanamine - 254824 2.7.11.26 1-(6-bromo-5-fluoro-1H-indol-3-yl)propan-2-one - 254825 2.7.11.26 1-(cyclopropylmethyl)-3-[4-(5,6-difluoro-1-benzofuran-3-yl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl]-1H-indole-5-carbonitrile - 39862 2.7.11.26 1-ethyl-3-(5-phenyl-1H-pyrazolo[3,4-b]pyridin-3-yl)urea - 77746 2.7.11.26 1-methyl-5-phenyl-1H-pyrazolo[3,4-b]pyridin-3-amine - 77789 2.7.11.26 1-methyl-6-(5-[[3-(trifluoromethyl)benzyl]sulfanyl]-1,3,4-oxadiazol-2-yl)-1H-benzimidazole - 77892 2.7.11.26 1-[3-(6-amino-9H-purin-9-yl)propyl]-3-methylpyridin-2(1H)-one ZINC91332506 254901 2.7.11.26 2-(1,3-benzodioxol-5-yl)-5-[(3-fluoro-4-methoxybenzyl)sulfanyl]-1,3,4-oxadiazole - 77896 2.7.11.26 2-(1-benzofuran-5-yl)-5-[[4-methoxy-3-(trifluoromethyl)benzyl]sulfanyl]-1,3,4-oxadiazole - 77881 2.7.11.26 2-(2,3-dihydro-1-benzofuran-5-yl)-5-[(3-fluoro-4-methoxybenzyl)sulfanyl]-1,3,4-oxadiazole - 77877 2.7.11.26 2-(2,3-dihydro-1-benzofuran-5-yl)-5-[(3-fluorobenzyl)sulfanyl]-1,3,4-oxadiazole - 77869 2.7.11.26 2-(2,3-dihydro-1-benzofuran-5-yl)-5-[(4-methoxybenzyl)sulfanyl]-1,3,4-oxadiazole - 77870 2.7.11.26 2-(2,3-dihydro-1-benzofuran-5-yl)-5-[2-(3-fluorophenyl)ethyl]-1,3,4-oxadiazole - 77893 2.7.11.26 2-(2,3-dihydro-1-benzofuran-5-yl)-5-[[(3-fluorophenyl)sulfanyl]methyl]-1,3,4-oxadiazole - 77895 2.7.11.26 2-(2,3-dihydro-1-benzofuran-5-yl)-5-[[3-(trifluoromethyl)benzyl]sulfanyl]-1,3,4-oxadiazole - 77876 2.7.11.26 2-(2,3-dihydro-1-benzofuran-5-yl)-5-[[4-methoxy-3-(trifluoromethyl)benzyl]sulfanyl]-1,3,4-oxadiazole - 77880 2.7.11.26 2-(3-ethylpiperazin-1-yl)-N-[6-(3-hydroxyphenyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]acetamide - 77771 2.7.11.26 2-(5,6-dibromo-1H-indol-3-yl)-N-methylethanamine - 255077 2.7.11.26 2-(5,6-dibromo-1H-indol-3-yl)ethanamine - 255078 2.7.11.26 2-(5,6-dichloro-1H-indol-3-yl)-N-methylethanamine - 255080 2.7.11.26 2-(5,6-dichloro-1H-indol-3-yl)ethanamine - 255081 2.7.11.26 2-(5,6-difluoro-1H-indol-3-yl)-N-methylethanamine - 255082 2.7.11.26 2-(5,6-difluoro-1H-indol-3-yl)ethanamine - 255083 2.7.11.26 2-(5-bromo-6-chloro-1H-indol-3-yl)-N-methylethanamine - 255090 2.7.11.26 2-(5-bromo-6-chloro-1H-indol-3-yl)ethanamine - 255091 2.7.11.26 2-(5-bromo-6-fluoro-1H-indol-3-yl)-N-methylethanamine - 255092 2.7.11.26 2-(5-bromo-6-fluoro-1H-indol-3-yl)ethanamine - 255093 2.7.11.26 2-(6-bromo-5-chloro-1H-indol-3-yl)-N-methylethanamine - 255106 2.7.11.26 2-(6-bromo-5-chloro-1H-indol-3-yl)ethanamine - 255107 2.7.11.26 2-(6-bromo-5-fluoro-1H-indol-3-yl)-N-methylethanamine - 255108 2.7.11.26 2-(6-bromo-5-fluoro-1H-indol-3-yl)ethanamine - 255109 2.7.11.26 2-(benzylsulfanyl)-5-(2,3-dihydro-1-benzofuran-5-yl)-1,3,4-oxadiazole - 77868 2.7.11.26 2-amino-N-(2'-(cyclohex-2''-enyl)acetyl)acetimide - 155568 2.7.11.26 2-amino-N-(2'-(phenyl)acetyl)propanimide - 155567 2.7.11.26 2-bromo-5-(7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)benzoate - 256807 2.7.11.26 2-chloro-5-[(2,5-dioxo-4-phenyl-2,5-dihydro-1H-pyrrol-3-yl)amino]benzoic acid - 77645 2.7.11.26 2-chloro-5-[[4-(2-chlorophenyl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl]amino]benzoic acid - 77653 2.7.11.26 2-chloro-5-[[4-(2-nitrophenyl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl]amino]benzoic acid - 77665 2.7.11.26 2-chloro-5-[[4-(3-chlorophenyl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl]amino]benzoic acid - 77670 2.7.11.26 2-chloro-5-[[4-(3-methoxyphenyl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl]amino]benzoic acid - 77676 2.7.11.26 2-chloro-5-[[4-(3-nitrophenyl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl]amino]benzoic acid - 77685 2.7.11.26 2-chloro-5-[[4-(4-chlorophenyl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl]amino]benzoic acid - 77694 2.7.11.26 2-cyanoethyl alsterpaullone - 155556 2.7.11.26 2-methyl-N-(5-phenyl-1H-pyrazolo[3,4-b]pyridin-3-yl)propanamide - 77744 2.7.11.26 2-[(2-chlorobenzyl)sulfanyl]-5-(2,3-dihydro-1-benzofuran-5-yl)-1,3,4-oxadiazole - 77871 2.7.11.26 2-[(3-chloro-4-methoxybenzyl)sulfanyl]-5-(2,3-dihydro-1-benzofuran-5-yl)-1,3,4-oxadiazole - 77878 2.7.11.26 2-[(3-chlorobenzyl)sulfanyl]-5-(2,3-dihydro-1-benzofuran-5-yl)-1,3,4-oxadiazole - 77872 2.7.11.26 2-[(4-chlorobenzyl)sulfanyl]-5-(2,3-dihydro-1-benzofuran-5-yl)-1,3,4-oxadiazole - 77873 2.7.11.26 2-[3-(4-methoxyphenyl)-1-benzofuran-5-yl]-5-[[3-(trifluoromethyl)benzyl]sulfanyl]-1,3,4-oxadiazole - 77887 2.7.11.26 2-[3-(4-methoxyphenyl)-1-benzofuran-5-yl]-5-[[4-methoxy-3-(trifluoromethyl)benzyl]sulfanyl]-1,3,4-oxadiazole - 77886 2.7.11.26 3-((5-((4-amino-4-methylcyclohexyl)amino)-pyrrolo[2,1-f][1,2,4] triazin-4-yl)amino)-5-bromophenol - 256808 2.7.11.26 3-(1-(2-(1H-imidazol-1-yl)ethyl)-1H-indol-3-yl)-4-(1H-pyrrolo[3,2-b]pyridin-1-yl)-1H-pyrrole-2,5-dione - 77861 2.7.11.26 3-(1-(2-morpholinoethyl)-1H-indol-3-yl)-4-(1H-pyrrol-3-yl)-1H-pyrrole-2,5-dione - 216293 2.7.11.26 3-(1-(3-(1H-imidazol-1-yl)propyl)-1H-indol-3-yl)-1-phenyl-4-(1H-pyrrolo[3,2-b]pyridin-1-yl)-1H-pyrrole-2,5-dione - 77849 2.7.11.26 3-(1-(3-(1H-imidazol-1-yl)propyl)-1H-indol-3-yl)-4-(1-methyl-1H-pyrrolo[3,2-b]pyridin-3-yl)-1H-pyrrole-2,5-dione - 77865 2.7.11.26 3-(1-(3-(1H-imidazol-1-yl)propyl)-1H-indol-3-yl)-4-(1H-pyrrol-3-yl)-1H-pyrrole-2,5-dione - 216294 2.7.11.26 3-(1-(3-(1H-imidazol-1-yl)propyl)-1H-indol-3-yl)-4-(1H-pyrrolo[3,2-b]pyridin-1-yl)-1H-pyrrole-2,5-dione - 77850 2.7.11.26 3-(1-(3-(dimethylamino)propyl)-1H-indol-3-yl)-4-(1H-pyrrolo[3,2-b]pyridin-1-yl)-1H-pyrrole-2,5-dione - 77855 2.7.11.26 3-(1-(3-(piperidin-1-yl)propyl)-1H-indol-3-yl)-4-(1H-pyrrol-3-yl)-1H-pyrrole-2,5-dione - 216295 2.7.11.26 3-(1-(3-(piperidin-1-yl)propyl)-1H-indol-3-yl)-4-(1H-pyrrolo[3,2-b]pyridin-1-yl)-1H-pyrrole-2,5-dione - 77859 2.7.11.26 3-(1-(3-hydroxypropyl)-1H-indol-3-yl)-4-(1-methyl-1H-pyrrolo[3,2-b]pyridin-3-yl)-1H-pyrrole-2,5-dione - 77867 2.7.11.26 3-(1-(3-hydroxypropyl)-1H-indol-3-yl)-4-(1H-pyrrol-3-yl)-1H-pyrrole-2,5-dione - 216296 2.7.11.26 3-(1-(3-morpholinopropyl)-1H-indol-3-yl)-4-(1H-1,2,4-triazol-1-yl)-1H-pyrrole-2,5-dione - 216297 2.7.11.26 3-(1-(3-morpholinopropyl)-1H-indol-3-yl)-4-(1H-pyrrol-3-yl)-1H-pyrrole-2,5-dione - 216298 2.7.11.26 3-(1-(3-morpholinopropyl)-1H-indol-3-yl)-4-(1H-pyrrolo[3,2-b]pyridin-1-yl)-1H-pyrrole-2,5-dione - 77860 2.7.11.26 3-(1-(4-(1H-imidazol-1-yl)butyl)-1H-indol-3-yl)-4-(1H-pyrrolo[3,2-b]pyridin-1-yl)-1H-pyrrole-2,5-dione - 77862 2.7.11.26 3-(1-(4-morpholinobutyl)-1H-indol-3-yl)-4-(1H-pyrrol-3-yl)-1H-pyrrole-2,5-dione - 216299 2.7.11.26 3-(1-benzofuran-3-yl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione - 77810 2.7.11.26 3-(1-benzofuran-3-yl)-4-(1-methyl-7-phenoxy-1H-indol-3-yl)-1H-pyrrole-2,5-dione - 77821 2.7.11.26 3-(1-benzofuran-3-yl)-4-(5-bromo-1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione - 77800 2.7.11.26 3-(1-benzofuran-3-yl)-4-(5-cyclopropyl-1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione - 77823 2.7.11.26 3-(1-benzofuran-3-yl)-4-(5-fluoro-1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione - 77808 2.7.11.26 3-(1-benzofuran-3-yl)-4-(5-fluoro-1H-indol-3-yl)-1H-pyrrole-2,5-dione - 77827 2.7.11.26 3-(1-benzofuran-3-yl)-4-(5-hydroxy-1H-indol-3-yl)-1H-pyrrole-2,5-dione - 77831 2.7.11.26 3-(1-benzofuran-3-yl)-4-(5-iodo-1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione - 77809 2.7.11.26 3-(1-benzofuran-3-yl)-4-(6-chloro-5-fluoro-1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione - 77819 2.7.11.26 3-(1-benzofuran-3-yl)-4-(6-chloro-5-methoxy-1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione - 77828 2.7.11.26 3-(1-benzofuran-3-yl)-4-(6-hydroxy-1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione - 77804 2.7.11.26 3-(1-benzofuran-3-yl)-4-(6-iodo-5-methoxy-1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione - 77822 2.7.11.26 3-(1-benzofuran-3-yl)-4-(7-hydroxy-1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione - 77813 2.7.11.26 3-(1-benzofuran-3-yl)-4-[1-(3-hydroxypropyl)-5-phenoxy-1H-indol-3-yl]-1H-pyrrole-2,5-dione - 77820 2.7.11.26 3-(1-benzofuran-3-yl)-4-[1-methyl-5-(morpholin-4-yl)-1H-indol-3-yl]-1H-pyrrole-2,5-dione - 77837 2.7.11.26 3-(1-benzofuran-3-yl)-4-[5-(benzyloxy)-1H-indol-3-yl]-1H-pyrrole-2,5-dione - 77838 2.7.11.26 3-(1-benzofuran-3-yl)-4-[5-bromo-1-(3-hydroxypropyl)-1H-indol-3-yl]-1H-pyrrole-2,5-dione - 77796 2.7.11.26 3-(1-benzofuran-3-yl)-4-[6-(benzyloxy)-1-methyl-1H-indol-3-yl]-1H-pyrrole-2,5-dione - 77835 2.7.11.26 3-(1-benzofuran-3-yl)-4-[7-(hydroxymethyl)-1-methyl-1H-indol-3-yl]-1H-pyrrole-2,5-dione - 77799 2.7.11.26 3-(1-benzofuran-3-yl)-4-[7-(methoxymethyl)-1-methyl-1H-indol-3-yl]-1H-pyrrole-2,5-dione - 77792 2.7.11.26 3-(1-methyl-1H-indol-3-yl)-4-(1H-pyrrol-3-yl)-1H-pyrrole-2,5-dione - 216301 2.7.11.26 3-(1-methyl-1H-pyrrolo[3,2-b]pyridin-3-yl)-4-(1-(2-morpholinoethyl)-1H-indol-3-yl)-1H-pyrrole-2,5-dione - 77866 2.7.11.26 3-(1-methyl-1H-pyrrolo[3,2-b]pyridin-3-yl)-4-(1-(3-morpholinopropyl)-1H-indol-3-yl)-1H-pyrrole-2,5-dione - 77864 2.7.11.26 3-(1H-imidazol-1-yl)-4-(1-(3-morpholinopropyl)-1H-indol-3-yl)-1H-pyrrole-2,5-dione - 216302 2.7.11.26 3-(1H-indol-3-yl)-4-(1H-pyrrol-3-yl)-1H-pyrrole-2,5-dione - 216303 2.7.11.26 3-(1H-indol-3-yl)-4-(1H-pyrrolo[3,2-b]pyridin-1-yl)-1H-pyrrole-2,5-dione - 77863 2.7.11.26 3-(2,3-dihydro-1H-indol-1-yl)-4-(2-methoxyphenyl)-1H-pyrrole-2,5-dione - 77708 2.7.11.26 3-(2,3-dihydro-1H-indol-1-yl)-4-(2-nitrophenyl)-1H-pyrrole-2,5-dione - 77709 2.7.11.26 3-(2,3-dihydro-1H-indol-1-yl)-4-(3-nitrophenyl)-1H-pyrrole-2,5-dione - 77711 2.7.11.26 3-(2,3-dihydro-1H-indol-1-yl)-4-(4-methoxyphenyl)-1H-pyrrole-2,5-dione - 77713 2.7.11.26 3-(2-chlorophenyl)-4-(2,3-dihydro-1H-indol-1-yl)-1H-pyrrole-2,5-dione - 77707 2.7.11.26 3-(2-chlorophenyl)-4-(phenylamino)-1H-pyrrole-2,5-dione - 77647 2.7.11.26 3-(2-chlorophenyl)-4-[(3,5-dichloro-4-hydroxyphenyl)amino]-1H-pyrrole-2,5-dione - 77651 2.7.11.26 3-(2-chlorophenyl)-4-[(3-chlorophenyl)amino]-1H-pyrrole-2,5-dione - 77648 2.7.11.26 3-(2-chlorophenyl)-4-[(3-hydroxyphenyl)amino]-1H-pyrrole-2,5-dione - 77649 2.7.11.26 3-(2-chlorophenyl)-4-[[4-(methylsulfanyl)phenyl]amino]-1H-pyrrole-2,5-dione - 77654 2.7.11.26 3-(2-methoxyphenyl)-4-(phenylamino)-1H-pyrrole-2,5-dione - 77655 2.7.11.26 3-(2-methoxyphenyl)-4-[[4-(methylsulfanyl)phenyl]amino]-1H-pyrrole-2,5-dione - 77660 2.7.11.26 3-(3-chlorophenyl)-4-(2,3-dihydro-1H-indol-1-yl)-1H-pyrrole-2,5-dione - 77710 2.7.11.26 3-(3-chlorophenyl)-4-[(3,5-dichloro-4-hydroxyphenyl)amino]-1H-pyrrole-2,5-dione - 77668 2.7.11.26 3-(3-chlorophenyl)-4-[(3-hydroxyphenyl)amino]-1H-pyrrole-2,5-dione - 77666 2.7.11.26 3-(3-chlorophenyl)-4-[[4-(methylsulfanyl)phenyl]amino]-1H-pyrrole-2,5-dione - 77671 2.7.11.26 3-(3-methoxyphenyl)-4-[[4-(methylsulfanyl)phenyl]amino]-1H-pyrrole-2,5-dione - 77677 2.7.11.26 3-(3-nitrophenyl)-4-(phenylamino)-1H-pyrrole-2,5-dione - 77678 2.7.11.26 3-(4-chlorophenyl)-4-(2,3-dihydro-1H-indol-1-yl)-1H-pyrrole-2,5-dione - 77712 2.7.11.26 3-(4-chlorophenyl)-4-(phenylamino)-1H-pyrrole-2,5-dione - 77687 2.7.11.26 3-(4-chlorophenyl)-4-[(3,5-dichloro-4-hydroxyphenyl)amino]-1H-pyrrole-2,5-dione - 77692 2.7.11.26 3-(4-chlorophenyl)-4-[(3-chlorophenyl)amino]-1H-pyrrole-2,5-dione - 77688 2.7.11.26 3-(4-chlorophenyl)-4-[(3-hydroxyphenyl)amino]-1H-pyrrole-2,5-dione - 77689 2.7.11.26 3-(4-chlorophenyl)-4-[(4-hydroxyphenyl)amino]-1H-pyrrole-2,5-dione - 77690 2.7.11.26 3-(4-chlorophenyl)-4-[methyl(phenyl)amino]-1H-pyrrole-2,5-dione - 77706 2.7.11.26 3-(4-chlorophenyl)-4-[[4-(methylsulfanyl)phenyl]amino]-1H-pyrrole-2,5-dione - 77695 2.7.11.26 3-(4-methoxyphenyl)-4-(phenylamino)-1H-pyrrole-2,5-dione - 77696 2.7.11.26 3-(4-methoxyphenyl)-4-[[4-(methylsulfanyl)phenyl]amino]-1H-pyrrole-2,5-dione - 77701 2.7.11.26 3-(5,6-difluoro-1-benzofuran-3-yl)-4-(1-methyl-1H-benzo[g]indol-3-yl)-1H-pyrrole-2,5-dione - 77825 2.7.11.26 3-(5,7-dibromo-1-methyl-1H-indol-3-yl)-4-(7-methoxy-1-benzofuran-3-yl)-1H-pyrrole-2,5-dione - 77814 2.7.11.26 3-(5-bromo-1-(3-(1H-imidazol-1-yl)propyl)-1H-indol-3-yl)-4-(1H-pyrrolo[3,2-b]pyridin-1-yl)-1H-pyrrole-2,5-dione - 77852 2.7.11.26 3-(5-bromo-1-benzofuran-3-yl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione - 77829 2.7.11.26 3-(5-bromo-1-methyl-1H-indol-3-yl)-4-(7-methoxy-1-benzofuran-3-yl)-1H-pyrrole-2,5-dione - 77801 2.7.11.26 3-(5-bromo-1-methyl-1H-indol-3-yl)-4-[6-(4-methoxyphenoxy)-1-benzofuran-3-yl]-1H-pyrrole-2,5-dione - 77826 2.7.11.26 3-(5-bromo-1-methyl-1H-indol-3-yl)-4-[6-(hydroxymethyl)-1-benzofuran-3-yl]-1H-pyrrole-2,5-dione - 77794 2.7.11.26 3-(5-bromo-1-methyl-1H-indol-3-yl)-4-[6-(prop-2-en-1-yloxy)-1-benzofuran-3-yl]-1H-pyrrole-2,5-dione - 77812 2.7.11.26 3-(5-bromo-1-methyl-1H-indol-3-yl)-4-[6-(prop-2-yn-1-yloxy)-1-benzofuran-3-yl]-1H-pyrrole-2,5-dione - 77807 2.7.11.26 3-(5-chloro-1-methyl-1H-indol-3-yl)-4-(5-fluoro-1-benzofuran-3-yl)-1H-pyrrole-2,5-dione - 77811 2.7.11.26 3-(5-fluoro-1-benzofuran-3-yl)-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione - 77830 2.7.11.26 3-(5-fluoro-1-benzofuran-3-yl)-4-(5-iodo-1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione - 77818 2.7.11.26 3-(5-fluoro-1-benzofuran-3-yl)-4-(6-hydroxy-1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione - 77803 2.7.11.26 3-(5-fluoro-1-methyl-1H-indol-3-yl)-4-(6-hydroxy-1-benzofuran-3-yl)-1H-pyrrole-2,5-dione - 77797 2.7.11.26 3-(5-fluoro-1-methyl-1H-indol-3-yl)-4-[6-(hydroxymethyl)-1-benzofuran-3-yl]-1H-pyrrole-2,5-dione - 77793 2.7.11.26 3-(5-fluoro-1-methyl-1H-indol-3-yl)-4-[6-(methoxymethyl)-1-benzofuran-3-yl]-1H-pyrrole-2,5-dione - 77806 2.7.11.26 3-(5-fluoro-6-iodo-1-methyl-1H-indol-3-yl)-4-(7-methoxy-1-benzofuran-3-yl)-1H-pyrrole-2,5-dione - 77824 2.7.11.26 3-(5-methoxy-1-(3-(1H-imidazol-1-yl)propyl)-1H-indol-3-yl)-4-(1H-pyrrolo[3,2-b]pyridin-1-yl)-1H-pyrrole-2,5-dione - 77851 2.7.11.26 3-(5-methoxy-1-(3-(dimethylamino)propyl)-1H-indol-3-yl)-4-(1H-pyrrolo[3,2-b]pyridin-1-yl)-1H-pyrrole-2,5-dione - 77856 2.7.11.26 3-(5-methoxy-1-(3-morpholinopropyl)-1H-indol-3-yl)-4-(1H-pyrrol-3-yl)-1H-pyrrole-2,5-dione - 216325 2.7.11.26 3-(5H-[1,3]dioxolo[4,5-f]indol-7-yl)-4-(5-fluoro-1-benzofuran-3-yl)-1H-pyrrole-2,5-dione - 77832 2.7.11.26 3-(6-bromo-1-(3-(1H-imidazol-1-yl)propyl)-1H-indol-3-yl)-4-(1H-pyrrolo[3,2-b]pyridin-1-yl)-1H-pyrrole-2,5-dione - 77853 2.7.11.26 3-(6-bromo-1-(3-(dimethylamino)propyl)-1H-indol-3-yl)-4-(1H-pyrrolo[3,2-b]pyridin-1-yl)-1H-pyrrole-2,5-dione - 77857 2.7.11.26 3-(6-bromo-1-(3-morpholinopropyl)-1H-indol-3-yl)-4-(1H-pyrrol-3-yl)-1H-pyrrole-2,5-dione - 216327 2.7.11.26 3-(6-chloro-1-(3-morpholinopropyl)-1H-indol-3-yl)-4-(1H-pyrrol-3-yl)-1H-pyrrole-2,5-dione - 216328 2.7.11.26 3-(6-chloro-5-fluoro-1-methyl-1H-indol-3-yl)-4-(6-methoxy-1-benzofuran-3-yl)-1H-pyrrole-2,5-dione - 77834 2.7.11.26 3-(6-chloro-5-fluoro-1-methyl-1H-indol-3-yl)-4-(7-methoxy-1-benzofuran-3-yl)-1H-pyrrole-2,5-dione - 77815 2.7.11.26 3-(6-chloro-5-fluoro-1-methyl-1H-indol-3-yl)-4-[6-(cyclobutylmethoxy)-1-benzofuran-3-yl]-1H-pyrrole-2,5-dione - 77839 2.7.11.26 3-(6-chloro-5-fluoro-1-methyl-1H-indol-3-yl)-4-[6-(cyclopropylmethoxy)-1-benzofuran-3-yl]-1H-pyrrole-2,5-dione - 77836 2.7.11.26 3-(6-chloro-5-fluoro-1-methyl-1H-indol-3-yl)-4-[6-(hydroxymethyl)-1-benzofuran-3-yl]-1H-pyrrole-2,5-dione - 77795 2.7.11.26 3-(6-fluoro-1-(3-(1H-imidazol-1-yl)propyl)-1H-indol-3-yl)-4-(1H-pyrrolo[3,2-b]pyridin-1-yl)-1H-pyrrole-2,5-dione - 77854 2.7.11.26 3-(6-fluoro-1-(3-(dimethylamino)propyl)-1H-indol-3-yl)-4-(1H-pyrrolo[3,2-b]pyridin-1-yl)-1H-pyrrole-2,5-dione - 77858 2.7.11.26 3-(6-fluoro-1-(3-morpholinopropyl)-1H-indol-3-yl)-4-(1Hpyrrol-3-yl)-1H-pyrrole-2,5-dione - 216329 2.7.11.26 3-(7-methoxy-1-benzofuran-3-yl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione - 77817 2.7.11.26 3-(7-methoxy-1-benzofuran-3-yl)-4-[1-methyl-6-(trifluoromethyl)-1H-indol-3-yl]-1H-pyrrole-2,5-dione - 77833 2.7.11.26 3-(imidazo[1,2-a]pyridin-3-yl)-4-[2-(morpholine-4-carbonyl)-1,2,3,4-tetrahydro[1,4]diazepino[6,7,1-hi]indol-7-yl]-1H-pyrrole-2,5-dione an imidazo[1,2-a]pyridinylindolylmaleimide 217182 2.7.11.26 3-(naphthalen-1-yl)-4-(1H-pyrrol-3-yl)-1H-pyrrole-2,5-dione - 216333 2.7.11.26 3-([[5-(2,3-dihydro-1-benzofuran-5-yl)-1,3,4-oxadiazol-2-yl]sulfanyl]methyl)benzo-nitrile - 77874 2.7.11.26 3-benzyl-N-[5-bromo-6-(furan-2-yl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrrolidine-1-carboxamide - 77740 2.7.11.26 3-phenyl-4-(1H-pyrrol-3-yl)-1H-pyrrole-2,5-dione - 216428 2.7.11.26 3-phenyl-4-(phenylamino)-1H-pyrrole-2,5-dione - 77640 2.7.11.26 3-[(2,5-dioxo-4-phenyl-2,5-dihydro-1H-pyrrol-3-yl)amino]benzoic acid - 77644 2.7.11.26 3-[(3,5-dichloro-4-hydroxyphenyl)amino]-4-(2-methoxyphenyl)-1H-pyrrole-2,5-dione - 77659 2.7.11.26 3-[(3,5-dichloro-4-hydroxyphenyl)amino]-4-(2-nitrophenyl)-1H-pyrrole-2,5-dione - 77664 2.7.11.26 3-[(3,5-dichloro-4-hydroxyphenyl)amino]-4-(3-methoxyphenyl)-1H-pyrrole-2,5-dione - 77674 2.7.11.26 3-[(3,5-dichloro-4-hydroxyphenyl)amino]-4-(3-nitrophenyl)-1H-pyrrole-2,5-dione - 77683 2.7.11.26 3-[(3,5-dichloro-4-hydroxyphenyl)amino]-4-(4-methoxyphenyl)-1H-pyrrole-2,5-dione - 77699 2.7.11.26 3-[(3,5-dichloro-4-hydroxyphenyl)amino]-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione - 77702 2.7.11.26 3-[(3,5-dichloro-4-hydroxyphenyl)amino]-4-phenyl-1H-pyrrole-2,5-dione - 77643 2.7.11.26 3-[(3-chloro-4-hydroxyphenyl)amino]-4-(2-chlorophenyl)-1H-pyrrole-2,5-dione - 77650 2.7.11.26 3-[(3-chloro-4-hydroxyphenyl)amino]-4-(2-methoxyphenyl)-1H-pyrrole-2,5-dione - 77658 2.7.11.26 3-[(3-chloro-4-hydroxyphenyl)amino]-4-(2-nitrophenyl)-1H-pyrrole-2,5-dione - 77663 2.7.11.26 3-[(3-chloro-4-hydroxyphenyl)amino]-4-(3-chlorophenyl)-1H-pyrrole-2,5-dione - 77667 2.7.11.26 3-[(3-chloro-4-hydroxyphenyl)amino]-4-(3-nitrophenyl)-1H-pyrrole-2,5-dione - 77682 2.7.11.26 3-[(3-chloro-4-hydroxyphenyl)amino]-4-(4-chlorophenyl)-1H-pyrrole-2,5-dione - 77691 2.7.11.26 3-[(3-chlorophenyl)amino]-4-(2-methoxyphenyl)-1H-pyrrole-2,5-dione - 77656 2.7.11.26 3-[(3-chlorophenyl)amino]-4-(2-nitrophenyl)-1H-pyrrole-2,5-dione - 77661 2.7.11.26 3-[(3-chlorophenyl)amino]-4-(3-methoxyphenyl)-1H-pyrrole-2,5-dione - 77672 2.7.11.26 3-[(3-chlorophenyl)amino]-4-(3-nitrophenyl)-1H-pyrrole-2,5-dione - 77679 2.7.11.26 3-[(3-chlorophenyl)amino]-4-(4-methoxyphenyl)-1H-pyrrole-2,5-dione - 77697 2.7.11.26 3-[(3-chlorophenyl)amino]-4-phenyl-1H-pyrrole-2,5-dione - 77641 2.7.11.26 3-[(3-hydroxyphenyl)amino]-4-(2-methoxyphenyl)-1H-pyrrole-2,5-dione - 77657 2.7.11.26 3-[(3-hydroxyphenyl)amino]-4-(2-nitrophenyl)-1H-pyrrole-2,5-dione - 77662 2.7.11.26 3-[(3-hydroxyphenyl)amino]-4-(3-methoxyphenyl)-1H-pyrrole-2,5-dione - 77673 2.7.11.26 3-[(3-hydroxyphenyl)amino]-4-(3-nitrophenyl)-1H-pyrrole-2,5-dione - 77680 2.7.11.26 3-[(3-hydroxyphenyl)amino]-4-(4-methoxyphenyl)-1H-pyrrole-2,5-dione - 77698 2.7.11.26 3-[(3-hydroxyphenyl)amino]-4-phenyl-1H-pyrrole-2,5-dione - 77642 2.7.11.26 3-[(4-hydroxyphenyl)amino]-4-(3-nitrophenyl)-1H-pyrrole-2,5-dione - 77681 2.7.11.26 3-[(5E)-5-methyl-4-oxo-2-hydroxy-5-octenyl]glutarimide - 155564 2.7.11.26 3-[(6,7-dimethoxyquinazolin-4-yl)amino]phenol - 256806 2.7.11.26 3-[([5-[1-(4-methoxyphenyl)-1H-benzimidazol-6-yl]-1,3,4-oxadiazol-2-yl]sulfanyl)methyl]benzonitrile - 77891 2.7.11.26 3-[([5-[3-(4-methoxyphenyl)-1-benzofuran-5-yl]-1,3,4-oxadiazol-2-yl]sulfanyl)methyl]benzonitrile - 77888 2.7.11.26 3-[1H-indol-3-yl]-4-[2-[4-methylpiperazin-1-yl]quinazolin-4-yl]-1H-pyrrole-2,5-dione enzyme binding structure analysis 216380 2.7.11.26 3-[4-(6-ethyl-1-benzofuran-3-yl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl]-1-methyl-1H-indole-5-carbonitrile - 77802 2.7.11.26 3-[5-(cyclopropylethynyl)-1-methyl-1H-indol-3-yl]-4-(5-fluoro-1-benzofuran-3-yl)-1H-pyrrole-2,5-dione - 77805 2.7.11.26 3-[5-[((4-amino-4-methylpiperidin-1-yl)methyl]pyrrolo[2,1-f][1,2,4]triazin-4-yl]amino)-5-bromophenol - 256795 2.7.11.26 3-[6-(4-chlorophenyl)-5-fluoro-1-methyl-1H-indol-3-yl]-4-(7-methoxy-1-benzofuran-3-yl)-1H-pyrrole-2,5-dione - 77840 2.7.11.26 3-[6-(benzyloxy)-1-methyl-1H-indol-3-yl]-4-(5-fluoro-1-benzofuran-3-yl)-1H-pyrrole-2,5-dione - 77816 2.7.11.26 3-[6-(hydroxymethyl)-1-benzofuran-3-yl]-4-[7-(hydroxymethyl)-1-methyl-1H-indol-3-yl]-1H-pyrrole-2,5-dione - 77798 2.7.11.26 3-[methyl(phenyl)amino]-4-(3-nitrophenyl)-1H-pyrrole-2,5-dione - 77705 2.7.11.26 3-[methyl(phenyl)amino]-4-phenyl-1H-pyrrole-2,5-dione - 77704 2.7.11.26 3-[[4-(2-chlorophenyl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl]amino]benzoic acid - 77652 2.7.11.26 3-[[4-(3-chlorophenyl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl]amino]benzoic acid - 77669 2.7.11.26 3-[[4-(3-methoxyphenyl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl]amino]benzoic acid - 77675 2.7.11.26 3-[[4-(3-nitrophenyl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl]amino]benzoic acid - 77684 2.7.11.26 3-[[4-(4-chlorophenyl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl]amino]benzoic acid - 77693 2.7.11.26 3-[[4-(4-methoxyphenyl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl]amino]benzoic acid - 77700 2.7.11.26 3-[[4-(methylsulfanyl)phenyl]amino]-4-(3-nitrophenyl)-1H-pyrrole-2,5-dione - 77686 2.7.11.26 3-[[4-(methylsulfanyl)phenyl]amino]-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione - 77703 2.7.11.26 3-[[4-(methylsulfanyl)phenyl]amino]-4-phenyl-1H-pyrrole-2,5-dione - 77646 2.7.11.26 3alpha,5alpha-tetrahydroprogesterone decreases only expression of GSK-3 beta in the cerebellum but not in the hypothalamus 138693 2.7.11.26 4,5-diphenyl-1H-pyrazolo[3,4-c]pyridazin-3-amine - 77783 2.7.11.26 4-(2-amino-5,6,7,8-tetrahydropyrimido[4',5':3,4]cyclohept[1,2-b]indol-11-yl)-2-methyl-3-butyn-2-ol - 256805 2.7.11.26 4-benzyl-2-methyl-1, 2, 4-thiadiazolidine-3,5-dione TDZD-8 155557 2.7.11.26 4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione - 77841 2.7.11.26 4-phenyl-1H-pyrazolo[3,4-b]pyridin-3-amine - 77787 2.7.11.26 4-[1-cyclohexyl-4-[4-fluorophenyl]-1H-imidazol-5-yl]pyrimidin-2-amine enzyme binding structure analysis 216538 2.7.11.26 4-[3-hydroxyanilino]-6,7-dimethoxyquinazoline - 256797 2.7.11.26 4-{(2R)-2-[(1R,3R,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl}piperidine-2,6-dione - 155565 2.7.11.26 5,6-dibromo-3-methyl-1H-indole - 255681 2.7.11.26 5,6-dibromo-3-phenyl-1H-indole best inhibitor for glycogen synthetase kinase-3 beta; best inhibitor for glycogen synthetase kinase-3 beta 255682 2.7.11.26 5,6-dichloro-3-methyl-1H-indole - 255683 2.7.11.26 5,6-dichloro-3-phenyl-1H-indole - 255684 2.7.11.26 5,6-difluoro-3-methyl-1H-indole - 255685 2.7.11.26 5,6-difluoro-3-phenyl-1H-indole - 255686 2.7.11.26 5,6-dihydroxy-2-(4-hydroxy-3-methoxycyclohexa-1,5-dien-1-yl)-7-methoxy-4H-chromen-4-one ZINC14644839 255687 2.7.11.26 5-(2,3-dihydro-1-benzofuran-5-yl)-N-(3-fluorobenzyl)-1,3,4-oxadiazol-2-amine - 77894 2.7.11.26 5-(5-[[4-methoxy-3-(trifluoromethyl)benzyl]sulfanyl]-1,3,4-oxadiazol-2-yl)-1H-indazole - 77883 2.7.11.26 5-([ [5-(2,3-dihydro-1-benzofuran-5-yl)-1,3,4-oxadiazol-2-yl]sulfanyl]methyl)-2-methoxybenzonitrile - 77879 2.7.11.26 5-bromo-6-chloro-3-methyl-1H-indole - 255708 2.7.11.26 5-bromo-6-chloro-3-phenyl-1H-indole - 255709 2.7.11.26 5-bromo-6-fluoro-3-methyl-1H-indole - 255710 2.7.11.26 5-bromo-6-fluoro-3-phenyl-1H-indole - 255711 2.7.11.26 5-phenyl-1H-pyrazolo[3,4-b]pyridin-3-amine - 77785 2.7.11.26 5-phenyl-1H-pyrazolo[3,4-c]pyridazin-3-amine - 77784 2.7.11.26 5-phenyl-1H-pyrazolo[3,4-c]pyridin-3-amine - 77786 2.7.11.26 5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-amine - 77791 2.7.11.26 5-phenyl[1,2]oxazolo[5,4-b]pyridin-3-amine - 77790 2.7.11.26 5-[2-phenylpyrazolo[1,5-a]pyridin-3-yl]-1h-pyrazolo[3,4-c]pyridazin-3-amine enzyme binding structure analysis 216593 2.7.11.26 5alpha-dihydroprogesterone decreases only expression of GSK-3 beta in the cerebellum but not in the hypothalamus 2395 2.7.11.26 6-(5-[[4-methoxy-3-(trifluoromethyl)benzyl]sulfanyl]-1,3,4-oxadiazol-2-yl)-1,3-benzothiazole - 77882 2.7.11.26 6-(5-[[4-methoxy-3-(trifluoromethyl)benzyl]sulfanyl]-1,3,4-oxadiazol-2-yl)imidazo[1,2-a]pyridine - 77884 2.7.11.26 6-(5-[[4-methoxy-3-(trifluoromethyl)benzyl]sulfanyl]-1,3,4-oxadiazol-2-yl)quinoline - 77885 2.7.11.26 6-bromo-5-chloro-3-methyl-1H-indole - 255769 2.7.11.26 6-bromo-5-chloro-3-phenyl-1H-indole - 255770 2.7.11.26 6-bromo-5-fluoro-3-methyl-1H-indole - 255771 2.7.11.26 6-bromo-5-fluoro-3-phenyl-1H-indole - 255772 2.7.11.26 6-bromo-5-methylindirubin-3'-oxime potent inhibitor 155560 2.7.11.26 6-bromo-indirubin-3'-acetoxime potent inhibitor 155559 2.7.11.26 6-bromo-indirubin-3'-oxime selective and potent GSK3beta inhibitor 39861 2.7.11.26 6-bromo-indirubin-3'-oxime potent inhibitor 39861 2.7.11.26 6-bromo-indirubin-3'-oxime - 39861 2.7.11.26 6-bromoindirubin-3'-oxim - 155576 2.7.11.26 6-bromoindirubin-3'-oxime - 155572 2.7.11.26 6-O-methyl-7-O-alpha-L-rhamnopyranosyldaidzein - 155569 2.7.11.26 7-methoxy-1-methyl-9h-betacarboline enzyme binding structure analysis 216758 2.7.11.26 7-O-alpha-L-rhamnopyranosyldaidzein - 155570 2.7.11.26 A-582941 attenuates beta-amyloid peptide 1-42-induced activation of GSK-3beta 146933 2.7.11.26 AlF4- - 16638 2.7.11.26 alpha-bungarotoxin attenuates beta-amyloid peptide 1-42-induced activation of GSK-3beta 146935 2.7.11.26 alsterpaullone - 4990 2.7.11.26 AMP-PNP ATP analogue adenosine 5'-(beta,gamma-imino)triphosphate 4099 2.7.11.26 AR-A014418 selective ATP-competitive inhibitor of GSK3 155577 2.7.11.26 ATP strongly inhibited by elevated concentrations of ATP uncomplexed with magnesium 4 2.7.11.26 BIIB-TTBKi-284 - 256804 2.7.11.26 Butyrolactone cdk5 inhibitor, isoenzyme TPKII 29830 2.7.11.26 Ca2+ - 15 2.7.11.26 caffeic acid 0.02 mg/ml caffeic acid decreases the activating phosphorylation of GSK-3beta 426 2.7.11.26 carteriosulfonic acid A low micromolar inhibitor of GSK-3beta 77842 2.7.11.26 carteriosulfonic acid B low micromolar inhibitor of GSK-3beta 77843 2.7.11.26 carteriosulfonic acid C low micromolar inhibitor of GSK-3beta 77844 2.7.11.26 CHIR98023 attenuates beta-amyloid peptide 1-42-induced activation of GSK-3beta 146932 2.7.11.26 compound C inhibits tau protein phosphorylation by AMPK 6303 2.7.11.26 convolutamine I - 256799 2.7.11.26 convolutamine J - 256800 2.7.11.26 CT99021 - 155555 2.7.11.26 CT99021 inhibition of GSK3 with CT99021 has little effect on the relative level of phosphorylation of Ser199 or Ser404 of human tau, but inhibition of GSK3beta using CT99021 results in dephosphorylation of endogenous c-Jun, Inh-2 and beta-catenin and dramatically increased c-Myc and beta-catenin expression 155555 2.7.11.26 cycloheximide - 1715 2.7.11.26 dantrolene in the presence of dantrolene, GSK-3beta activation and tau phosphorylation are decreased 18799 2.7.11.26 disheveled protein - 155573 2.7.11.26 DMSO complete inhibition at 0.4% (v/v) 896 2.7.11.26 enzastaurin activation-related phosphorylation of Y216/Y276 is dramatically decreased following exposure to enzastaurin whereas the inhibitory phosphorylation of S21 is significantly up-regulated in glioma cells. GSK3 inhibition results in glioma cell death and reduced tumorigenicity 25838 2.7.11.26 GF 109203X - 39845 2.7.11.26 GF 109203X a benzofuranylindolylmaleimide 39845 2.7.11.26 GSK-3 inhibitor IX - 155562 2.7.11.26 GSK3betaI 0.0001 mM 146931 2.7.11.26 GTPgamma-S - 155563 2.7.11.26 Insulin insulin induces phosphorylation of the Ser9 residue, thereby inactivating GSK-3beta 524 2.7.11.26 insulin-like growth factor-I - 77845 2.7.11.26 kenpaullone - 6875 2.7.11.26 kororamide A - 256801 2.7.11.26 kororamide B - 256802 2.7.11.26 KRM-189 74% inhibition at 0.01 mM, competes with ATP for GSK-3beta, leading to decreased Vmax and constant Km with increasing concentrations of ATP 77898 2.7.11.26 KRM-191 84% inhibition at 0.01 mM, competes with ATP for GSK-3beta, leading to decreased Vmax and constant Km with increasing concentrations of ATP 77899 2.7.11.26 KRM-192 75% inhibition at 0.01 mM 77900 2.7.11.26 KRM-195 80% inhibition at 0.01 mM 77901 2.7.11.26 KRM-296 65% inhibition at 0.01 mM 77902 2.7.11.26 KRM-7777 65% inhibition at 0.01 mM 77897 2.7.11.26 leptin - 3532 2.7.11.26 LiCl slight inhibition of T231 phosphorylation by p25-Cdk5 kinase complex 815 2.7.11.26 LiCl pharmacological inhibition of GSK3 in old transgenic mice by chronic treatment with lithium, leads to a reduction of the age-dependent increase in tau hyperphosphorylation 815 2.7.11.26 LiCl 10 mM 815 2.7.11.26 LiCl - 815 2.7.11.26 LiCl 71% inhibition at 0.01 mM 815 2.7.11.26 LiCl lithium is a weak inhibitor of GSK3beta, lithium dose-dependently inhibits GSK3beta through the phosphorylation of serine 9 residue 815 2.7.11.26 LiCl GSK-3-specific inhibitor 815 2.7.11.26 LiCl complete inhibition at 2 mM 815 2.7.11.26 LiCl a dose-dependent increase in phosphorylation of GSK-3beta occurs after treatment with LiCl (5-20 mM) 815 2.7.11.26 lithium after inhibition of GSK-3 in cortical neurons, the splicing factor SC35 is nuclearly redistributed and enriched in nuclear speckles and colocalizes with the kinase 6242 2.7.11.26 lithium - 6242 2.7.11.26 lithium selective inhibition of GSK-3, blocks tau hyperphosphorylation either in cultured neurons or in rat brain 6242 2.7.11.26 lithium chloride 15 mM 38235 2.7.11.26 lithium chloride - 38235 2.7.11.26 meridianin F - 256803 2.7.11.26 methyl 2-bromo-5-(7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)benzoate - 256796 2.7.11.26 methyl 3-([[5-(2,3-dihydro-1-benzofuran-5-yl)-1,3,4-oxadiazol-2-yl]sulfanyl]methyl)benzoate - 77875 2.7.11.26 methyllycaconitine attenuates beta-amyloid peptide 1-42-induced activation of GSK-3beta 146934 2.7.11.26 additional information phosphorylation of GSK3beta at S9 inhibits the enzyme 2 2.7.11.26 additional information no inhibition of the p25-Cdk5 kinase complex by PD98059 and SB203580 2 2.7.11.26 additional information phosphorylation of GSK3beta at S9 inhibits the enzyme, the phosphorylation at Ser9 is inhibited by wortmannin or GF-109203X, this inhibition is eliminated by inhibition of GSK-3 by a different inhibitor 2 2.7.11.26 additional information inactivating phosphorylation of Ser9 of TPKI/GSK3beta in close correspondence with tau phosphorylation 2 2.7.11.26 additional information Cdk5 over-activation leads to inhibition of GSK3 in young transgenic mice, in old transgenic animals the inhibition of GSK3 is lost 2 2.7.11.26 additional information N-terminus negatively regulates tau phosphorlyation by blocking GSK3beta access, local conformational change induced by T231 phosphorylation is required for the phosphorylation of the C-terminus and hyperphosphorylation of tau 2 2.7.11.26 additional information inhibition of GSK3 activity results in c-MYC activation, leading to the induction of Bax, Bim, DR4/DR5, and tumor necrosis factor-related apoptosis-inducing ligand expression and subsequent cytotoxicity. inhibition of GSK3 activity causes a dramatic decrease in intracellular nuclear factor-kappaB activity. Inhibition of GSK3 activity results in c-MYC-dependent glioma cell death through multiple mechanisms, all of which converge on the apoptotic pathways 2 2.7.11.26 additional information cdk5 can negatively regulate GSK3beta activity through neuregulin/ErbB signaling, phosphorylation at the inhibitory GSK3beta-Ser9 site activates GSK3beta 2 2.7.11.26 additional information Galphaq protein inhibits GSK-3beta via activation of protein kinase C 2 2.7.11.26 additional information protein tau-associated novel protein kinase Cepsilon suppresses the GSK-3beta-mediated phosphorylation of protein tau through the phosphorylation of GSK-3beta by the kinase in vitro 2 2.7.11.26 additional information not inhibited by 2-(2,3-dihydro-1-benzofuran-5-yl)-5-[(3-fluorobenzyl)oxy]-1,3,4-oxadiazole 2 2.7.11.26 additional information galectin-3 regulates GSK-3beta activity/phosphorylation via the PI3K/AKT pathway 2 2.7.11.26 additional information the 3-nitropropionic acid treatment induces GSK-3beta truncation, calpeptin prevents GSK-3beta cleavage and cell death induced by 3-nitropropionic acid 2 2.7.11.26 additional information not inhibited by indirubin, indirubin-3'-oxime, 5-bromo-indirubin, 5-aminoindirubin-3'-oxime, 6-bromo-indirubin, 6-bromo-N-methyl-indirubin-3'-oxime, 6-bromo-N-methyl-indirubin-3'-acetoxime, 6-bromo-indirubin-3'diethyl phosphatoxime, indirubin-3'-methoxime, 6-bromo-5-nitroindirubin, 6-bromo-5-nitroindirubin-3'-oxime, and 6-bromo-5-methylindirubin 2 2.7.11.26 additional information treatment with 1 CFU/cell bacillus Calmette-Guerin increases the phosphorylation of GSK3beta at serine 9 and therefore inhibits the activity to about 40% 1 h after stimulation 2 2.7.11.26 additional information the crude organic extract of fermentation cultures of Streptomyces sp. strain H7667 inhibits growth of a yeast transformant (with cloned human GSK-3beta) at 37°C, but shows no inhibition at 25°C 2 2.7.11.26 additional information desacyl-carteriosulfonic acid shows no GSK-3beta inhibitory activity at concentrations up to 0.05 mM 2 2.7.11.26 additional information design, synthesis, and evaluation of 3-aryl-4-pyrrolyl-maleimides as glycogen synthase kinase-3beta inhibitors. Compounds 3-(1-(3-morpholinopropyl)-1H-indol-3-yl)-4-(1H-pyrrol-3-yl)-1H-pyrrole-2,5-dione, 3-(1-(3-(1H-imidazol-1-yl)propyl)-1H-indol-3-yl)-4-(1H-pyrrol-3-yl)-1H-pyrrole-2,5-dione, 3-(6-fluoro-1-(3-morpholinopropyl)-1H-indol-3-yl)-4-(1Hpyrrol-3-yl)-1H-pyrrole-2,5-dione, 3-(1-(3-hydroxypropyl)-1H-indol-3-yl)-4-(1H-pyrrol-3-yl)-1H-pyrrole-2,5-dione, and 3-(1-methyl-1H-indol-3-yl)-4-(1H-pyrrol-3-yl)-1H-pyrrole-2,5-dione significantly reduce amyloidbeta-induced Tau hyperphosphorylation, showing the inhibition of GSK-3beta at the cellular level. Structure-activity relationships, in silico molecular modeling study, overview 2 2.7.11.26 additional information inhibitor development using seven different scaffolds, scaffold 3-aminopyrrolidine exhibits high preferential affinity with GSK3beta. Interaction analysis of inhibitor scaffolds with different protein kinases, overview 2 2.7.11.26 additional information activation of EphB2 receptor kinase arrests tau hyperphosphorylation through PI3K-/Akt-mediated GSK-3beta inhibition. EphrinB1/Fc treatment induces tyrosine phosphorylation (activation) of EphB2, while deletion of the tyrosine kinase domain (VM) of EphB2 eliminates the receptor stimulation-induced GSK-3beta inhibition and tau dephosphorylation 2 2.7.11.26 additional information stimulation of EphB2 upregulates PI3K and Akt causing inhibition of GSK-3beta 2 2.7.11.26 additional information GSK-3 is inactivated by phosphorylation of serine 9 in GSK-3beta and serine 21 in GSK-3alpha subunits by mainly Akt. Hyperglycemia induces strong activity of GSK-3 in rat brain 2 2.7.11.26 N-(1H-pyrazolo[3,4-b]pyridin-3-yl)butanamide - 77748 2.7.11.26 N-(4,5-diphenyl-1H-pyrazolo[3,4-c]pyridazin-3-yl)butanamide - 77717 2.7.11.26 N-(4-ethoxy-3-fluorobenzyl)-9H-purin-6-amine ZINC69775110 256098 2.7.11.26 N-(5,6-diphenyl-1H-pyrazolo[3,4-b]pyridin-3-yl)cyclopropanecarboxamide - 77765 2.7.11.26 N-(5-bromo-6-phenyl-1H-pyrazolo[3,4-b]pyridin-3-yl)-4-methylpiperidine-1-carboxamide - 77768 2.7.11.26 N-(5-bromo-6-phenyl-1H-pyrazolo[3,4-b]pyridin-3-yl)cyclopropanecarboxamide - 77725 2.7.11.26 N-(5-chloro-6-phenyl-1H-pyrazolo[3,4-b]pyridin-3-yl)cyclopropanecarboxamide - 77766 2.7.11.26 N-(5-cyano-6-phenyl-1H-pyrazolo[3,4-b]pyridin-3-yl)cyclopropanecarboxamide - 77767 2.7.11.26 N-(5-phenyl-1H-indazol-3-yl)butanamide - 77714 2.7.11.26 N-(5-phenyl-1H-pyrazolo[3,4-b]pyridin-3-yl)acetamide - 77741 2.7.11.26 N-(5-phenyl-1H-pyrazolo[3,4-b]pyridin-3-yl)butanamide - 77743 2.7.11.26 N-(5-phenyl-1H-pyrazolo[3,4-b]pyridin-3-yl)cyclopentanecarboxamide - 77745 2.7.11.26 N-(5-phenyl-1H-pyrazolo[3,4-b]pyridin-3-yl)methanesulfonamide - 77788 2.7.11.26 N-(5-phenyl-1H-pyrazolo[3,4-b]pyridin-3-yl)propanamide - 77742 2.7.11.26 N-(5-phenyl-1H-pyrazolo[3,4-c]pyridin-3-yl)butanamide - 77715 2.7.11.26 N-(5-phenyl-1H-pyrazolo[4,3-d]pyrimidin-3-yl)butanamide - 77716 2.7.11.26 N-(6-phenyl-1H-indazol-3-yl)cyclopropanecarboxamide - 77773 2.7.11.26 N-(6-phenyl-1H-pyrazolo[3,4-b]pyridin-3-yl)cyclopropanecarboxamide - 77758 2.7.11.26 N-[3-cyano-6-[3-[1-piperidinyl]propanoyl]-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl]1-naphthalenecarboxamide enzyme binding structure analysis 217785 2.7.11.26 N-[4-[3-(4-ethylpiperazin-1-yl)propyl]-5-phenyl-1H-pyrazolo[3,4-c]pyridazin-3-yl]butanamide - 77720 2.7.11.26 N-[4-[3-(dimethylamino)propyl]-5-phenyl-1H-pyrazolo[3,4-c]pyridazin-3-yl]butanamide - 77718 2.7.11.26 N-[4-[3-(morpholin-4-yl)propyl]-5-phenyl-1H-pyrazolo[3,4-c]pyridazin-3-yl]butanamide - 77721 2.7.11.26 N-[4-[ethyl(piperidin-1-ylmethyl)amino]-5-phenyl-1H-pyrazolo[3,4-c]pyridazin-3-yl]butanamide - 77723 2.7.11.26 N-[4-[methyl(piperidin-1-yl)amino]-5-phenyl-1H-pyrazolo[3,4-c]pyridazin-3-yl]butanamide - 77722 2.7.11.26 N-[5-(2,3-difluorophenyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]butanamide - 77751 2.7.11.26 N-[5-(2-chlorophenyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]butanamide - 77752 2.7.11.26 N-[5-(2-fluorophenyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]butanamide - 77749 2.7.11.26 N-[5-(3-fluorophenyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]butanamide - 77750 2.7.11.26 N-[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazolo[3,4-b]pyridin-3-yl]butanamide - 77747 2.7.11.26 N-[5-(6,6-difluorocyclohexa-1,3-dien-1-yl)-4-[3-(dimethylamino)propyl]-1H-pyrazolo[3,4-c]pyridazin-3-yl]butanamide - 77724 2.7.11.26 N-[5-(biphenyl-4-yl)-1H-pyrazolo[3,4-b]pyridin-3-yl]butanamide - 77755 2.7.11.26 N-[5-(naphthalen-1-yl)-1H-pyrazolo[3,4-b]pyridin-3-yl]butanamide - 77757 2.7.11.26 N-[5-(naphthalen-2-yl)-1H-pyrazolo[3,4-b]pyridin-3-yl]butanamide - 77756 2.7.11.26 N-[5-(pyridin-3-yl)-1H-pyrazolo[3,4-b]pyridin-3-yl]butanamide - 77753 2.7.11.26 N-[5-(pyridin-4-yl)-1H-pyrazolo[3,4-b]pyridin-3-yl]butanamide - 77754 2.7.11.26 N-[5-bromo-6-(4-hydroxyphenyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-4-(4-ethylpiperazin-1-yl)butanamide - 77731 2.7.11.26 N-[5-bromo-6-(4-hydroxyphenyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-4-methylpiperidine-1-carboxamide - 77770 2.7.11.26 N-[5-bromo-6-(4-hydroxyphenyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]cyclopropanecarboxamide - 77726 2.7.11.26 N-[5-bromo-6-(furan-2-yl)-1H-pyrazolo[3,4-b]pyridin-3-yl]cyclopropanecarboxamide - 77736 2.7.11.26 N-[5-bromo-6-(tetrahydrothiophen-3-yl)-1H-pyrazolo[3,4-b]pyridin-3-yl]cyclopropanecarboxamide - 77738 2.7.11.26 N-[5-bromo-6-(thiophen-2-yl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-2-(4-methylpiperidin-1-yl)acetamide - 77739 2.7.11.26 N-[5-bromo-6-(thiophen-2-yl)-1H-pyrazolo[3,4-b]pyridin-3-yl]cyclopropanecarboxamide - 77734 2.7.11.26 N-[5-chloro-6-(4-hydroxyphenyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]cyclopropanecarboxamide - 77763 2.7.11.26 N-[5-phenyl-4-[3-(pyrrolidin-1-yl)propyl]-1H-pyrazolo[3,4-c]pyridazin-3-yl]butanamide - 77719 2.7.11.26 N-[6-(1H-indol-5-yl)-1H-indazol-3-yl]cyclopropanecarboxamide - 77775 2.7.11.26 N-[6-(2,5-difluorophenyl)-1H-indazol-3-yl]cyclopropanecarboxamide - 77782 2.7.11.26 N-[6-(2-hydroxyphenyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]cyclopropanecarboxamide - 77761 2.7.11.26 N-[6-(2-methoxyphenyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]cyclopropanecarboxamide - 77762 2.7.11.26 N-[6-(2H-pyrrol-2-yl)-1H-indazol-3-yl]cyclopropanecarboxamide - 77778 2.7.11.26 N-[6-(3,4-dihydroxyphenyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]cyclopropanecarboxamide - 77759 2.7.11.26 N-[6-(3-bromo-4-hydroxyphenyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]cyclopropanecarboxamide - 77728 2.7.11.26 N-[6-(3-chloro-4-hydroxyphenyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]cyclopropanecarboxamide - 77729 2.7.11.26 N-[6-(3-fluorophenyl)-1H-indazol-3-yl]cyclopropanecarboxamide - 77777 2.7.11.26 N-[6-(3-hydroxyphenyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]cyclopropanecarboxamide - 77732 2.7.11.26 N-[6-(3-methoxyphenyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]cyclopropanecarboxamide - 77760 2.7.11.26 N-[6-(3-sulfamoylphenyl)-1H-indazol-3-yl]cyclopropanecarboxamide - 77776 2.7.11.26 N-[6-(4-hydroxyphenyl)-1H-indazol-3-yl]cyclopropanecarboxamide - 77774 2.7.11.26 N-[6-(4-hydroxyphenyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-4-methylpiperidine-1-carboxamide - 77769 2.7.11.26 N-[6-(4-hydroxyphenyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]cyclopropanecarboxamide - 77727 2.7.11.26 N-[6-(4-hydroxyphenyl)-5-methyl-1H-pyrazolo[3,4-b]pyridin-3-yl]cyclopropanecarboxamide - 77764 2.7.11.26 N-[6-(4-hydroxyphenyl)-5-phenyl-1H-pyrazolo[3,4-b]pyridin-3-yl]cyclopropanecarboxamide - 77730 2.7.11.26 N-[6-(4-methoxyphenyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]cyclopropanecarboxamide - 77772 2.7.11.26 N-[6-(furan-2-yl)-1H-pyrazolo[3,4-b]pyridin-3-yl]cyclopropanecarboxamide - 77735 2.7.11.26 N-[6-(furan-3-yl)-1H-indazol-3-yl]cyclopropanecarboxamide - 77779 2.7.11.26 N-[6-(tetrahydrothiophen-3-yl)-1H-pyrazolo[3,4-b]pyridin-3-yl]cyclopropanecarboxamide - 77737 2.7.11.26 N-[6-(thiophen-2-yl)-1H-indazol-3-yl]cyclopropanecarboxamide - 77780 2.7.11.26 N-[6-(thiophen-2-yl)-1H-pyrazolo[3,4-b]pyridin-3-yl]cyclopropanecarboxamide - 77733 2.7.11.26 N-[6-(thiophen-3-yl)-1H-indazol-3-yl]cyclopropanecarboxamide - 77781 2.7.11.26 naramycin B - 155566 2.7.11.26 Nicotine attenuates beta-amyloid peptide 1-42-induced activation of GSK-3beta 2572 2.7.11.26 p25 p25 overexpressing mice have reduced GSK3beta activity 3154 2.7.11.26 progesterone decreases expression and phosphorylation of GSK-3 beta in the cerebellum but not in the hypothalamus, regulation of tau expression and phosphorylation by progesterone may contribute to the hormonal regulation of cerebellar function by the modification of neuronal cytoskeleton 286 2.7.11.26 Protein kinase C protein kinase C inhibits GSK-3beta by phosphorylating its auto-inhibitory domain at Ser9 2675 2.7.11.26 Ro 31-8220 - 32955 2.7.11.26 Ro 31-8220 a benzofuranylindolylmaleimide 32955 2.7.11.26 roscovitine complete inhibition of T231 phosphorylation by 25-Cdk5 kinase complex 994 2.7.11.26 roscovitine inhibition of CDK5 994 2.7.11.26 roscovitine Cdk5 inhibitor 994 2.7.11.26 SB 216763 GSK-3-specific inhibitor 155554 2.7.11.26 SB 216763 - 155554 2.7.11.26 SB-216763 specific inhibitor of GSK-3beta 77846 2.7.11.26 SB-216763 selective ATP-competitive inhibitor of GSK3 77846 2.7.11.26 SB-415286 - 77639 2.7.11.26 SB-415286 complete inhibition at 0.005 mM 77639 2.7.11.26 SB216763 specific GSK-3 inhibitor 39860 2.7.11.26 SB216763 potent and selective cell permeable ATP-competitive inhibitor of GSK3 39860 2.7.11.26 SB216763 - 39860 2.7.11.26 SB415286 - 155578 2.7.11.26 SRN-003-556 - 155575 2.7.11.26 staurosporine - 886 2.7.11.26 staurosporine a benzofuranylindolylmaleimide 886 2.7.11.26 TDZD-8 selective GSK-3beta inhibitor, induces phosphorylation of the Ser9 residue, thereby inactivating GSK-3beta 72003 2.7.11.26 tideglusib irreversible inhibitor 256798 2.7.11.26 trans-activating transcriptor-eIF2B acts as a competitive inhibitor of GSK-3 77848 2.7.11.26 ZM336372 inhibits GSK-3beta through phosphorylation at Ser9, a dose-dependent increase in phosphorylation of GSK-3beta occurs after treatment with ZM336372 (0.025-0.1 mM) 155574 2.7.11.26 [3R]-1-[5-methyl-7Hpyrrolo[2,3-d]pyrimidin-4-yl]pyrrolidin-3-amine enzyme binding structure analysis 216117