2.3.1.47 2,3-dichloronaphthalene-1,4-dione - 87366 2.3.1.47 2-(furan-2-yl)-1H-benzimidazole - 87364 2.3.1.47 2-[(1,1,2,2-tetrachloroethyl)sulfanyl]-3a,4,7,7a-tetrahydro-1H-isoindole-1,3(2H)-dione - 87385 2.3.1.47 2-[(trichloromethyl)sulfanyl]-3a,4,7,7a-tetrahydro-1H-isoindole-1,3(2H)-dione - 87386 2.3.1.47 3-([4-[(2-fluorophenyl)amino]phenyl]disulfanyl)-1H-1,2,4-triazole-1-carboxamide - 210124 2.3.1.47 3-([4-[(3,4-difluorophenyl)amino]phenyl]disulfanyl)-1H-1,2,4-triazole-1-carboxamide - 210120 2.3.1.47 3-([4-[(3,5-difluorophenyl)amino]phenyl]disulfanyl)-1H-1,2,4-triazole-1-carboxamide - 210121 2.3.1.47 3-([4-[(4-fluorophenyl)amino]phenyl]disulfanyl)-1H-1,2,4-triazole-1-carboxamide - 210123 2.3.1.47 3-([4-[(4-nitrophenyl)amino]phenyl]disulfanyl)-1H-1,2,4-triazole-1-carboxamide - 210122 2.3.1.47 3-[[4-(benzylamino)phenyl]disulfanyl]-1H-1,2,4-triazole-1-carboxamide - 210119 2.3.1.47 4-(1H-inden-3-yl)naphthalene-1,2-dione - 87361 2.3.1.47 5,10-dioxo-5,10-dihydronaphtho[2,3-b][1,4]dithiine-2,3-dicarbonitrile - 87389 2.3.1.47 5,8-dihydronaphthalene-1,4-dione - 87362 2.3.1.47 5,8-dihydroxynaphthalene-1,4-dione - 87359 2.3.1.47 5-hydroxy-2-methylnaphthalene-1,4-dione - 87380 2.3.1.47 5-hydroxynaphthalene-1,4-dione - 87358 2.3.1.47 Ag+ - 75 2.3.1.47 biotin - 143 2.3.1.47 Co2+ - 23 2.3.1.47 Cu2+ - 19 2.3.1.47 D-alanine - 164 2.3.1.47 D-cycloserine - 874 2.3.1.47 D-histidine - 3068 2.3.1.47 D/L-histidine - 6510 2.3.1.47 glycine - 72 2.3.1.47 hydroxylamine - 85 2.3.1.47 L-cysteine - 74 2.3.1.47 L-histidine - 349 2.3.1.47 L-serine - 95 2.3.1.47 methyl 3-(5,6-dioxo-5,6-dihydronaphthalen-2-yl)propanoate - 87382 2.3.1.47 methyl 3-[8-(1H-inden-3-yl)-5,6-dioxo-5,6-dihydronaphthalen-2-yl]propanoate - 87360 2.3.1.47 methyl 3-[8-[(4-fluorophenyl)amino]-5,6-dioxo-5,6-dihydronaphthalen-2-yl]propanoate - 87384 2.3.1.47 methyl 3-[8-[(4-methylphenyl)amino]-5,6-dioxo-5,6-dihydronaphthalen-2-yl]propanoate - 87383 2.3.1.47 N-[dichloro(fluoro)-l4-sulfanyl]-N',N'-dimethyl-N-phenylsulfuric diamide - 87387 2.3.1.47 N-[dichloro(fluoromethyl)-lambda4-sulfanyl]-N',N'-dimethyl-N-(4-methylphenyl)sulfuric diamide - 87388 2.3.1.47 naphthalene-1,2-dione - 20431 2.3.1.47 Ni2+ - 38 2.3.1.47 phenylhydrazine - 398 2.3.1.47 Plumbagin - 2580 2.3.1.47 Pyruvic acid - 1725 2.3.1.47 Semicarbazide - 382 2.3.1.47 triphenyltin acetate - 87742 2.3.1.47 8-amino-7-oxooctanoic acid achiral analog of substrate, strong inhibitor of both enzyme forms, binding to active site 19108 2.3.1.47 trifluoroalanine binding structure, irreversible suicide inhibition of the enzyme, involves decarboxylative defluorination of the inhibitor-PLP aldimine followed by attack of the conjugated imine by the amino group of the active site lysine to afford a covalently bound difluorinated intermediate, which can subsequently undergo further HF losses and hydrolysis to afford a 2-(pyridoximine phosphate) acetoyl protein adduct 135410 2.3.1.47 2-amino-3-hydroxy-2-methylnonadioic acid competitive, transition state analogue 50484 2.3.1.47 4-carboxybutyl(1-amino-1-carboxyethyl)phosphonate competitive, transition state analogue 50523 2.3.1.47 D-alanine competitive; Schiff base formation between D- or L-alanine and pyridoxal-5'-phophate in the active site 164 2.3.1.47 additional information concentration above 10 mM of Ca2+, Mg2+, and Mn2+ cause slow precipitation of the enzyme 2 2.3.1.47 triphenyltin acetate herbicidal activity (foliar treatment) under greenhouse conditions 87742 2.3.1.47 pyridoxal 5'-phosphate high concentrations 32 2.3.1.47 N-(2-fluorophenyl)-3-(phenyldisulphanyl)-1H-1,2,4-triazole-1-carboxamide i.e. KHG23844, induces 2.3fold higher L-alanine accumulation in the treated Arabidopsis thaliana plants. 45-day old Arabidopsis thaliana plants are completely killed by the compound. Foliar supplement of 1 mM biotin at 1 and 2 days before KHG23844 application effectively recovers the growth inhibition of plants treated with the inhibitor 210118 2.3.1.47 additional information inhibition mechanism; no inhibition by 8-amino-7-oxo-8-phosphonononanoic acid 2 2.3.1.47 D-penicillamine L-enantiomer not as effective 2733 2.3.1.47 additional information no inhibition by D-alanine 2 2.3.1.47 additional information no inhibition by HgCl2, EDTA, 2,2'-dipyridyl, oxalate, KCN, various amino acids 2 2.3.1.47 (R)-8-amino-7-oxononanoic acid no inhibition up to 15 microM with 94.6% ee (S)-enantiomer as substrate, beyond that strong inhibitor of both enzyme forms, binding to active site 5854 2.3.1.47 D-KAPA product inhibition 62427 2.3.1.47 8-Amino-7-oxononanoate product inhibition in vivo 1494 2.3.1.47 L-cysteine strong 74 2.3.1.47 8-amino-7-oxo-8-phosphonononanoic acid strong inhibition 50594 2.3.1.47 1,10-phenanthroline to some extent 62 2.3.1.47 citrate to some extent 131 2.3.1.47 diisopropyl fluorophosphate to some extent 244 2.3.1.47 isoniazide to some extent 10677 2.3.1.47 additional information triazolyl phenyl disulfides as 8-amino-7-oxononanoate synthase inhibitors, overview 2 2.3.1.47 Cd2+ weak 52 2.3.1.47 Zn2+ weak 14