2.3.1.39 acetoacetyl-CoA inhibition of both isozymes at 0.02 mM and at 0.1 mM 187 2.3.1.39 acetyl-CoA competitive to malonyl-CoA 29 2.3.1.39 acetyl-CoA - 29 2.3.1.39 apomorphine - 92466 2.3.1.39 boldine - 23564 2.3.1.39 CaCl2 1 mM, 17% inhibition 218 2.3.1.39 CoA - 18 2.3.1.39 CoA kinetics 18 2.3.1.39 CoA not inhibitory 18 2.3.1.39 corytuberine - 87741 2.3.1.39 diethyldicarbonate inhibits MCT1 but not MCT2 at 1 mM 310 2.3.1.39 EDTA 63% inhibition at 1 mM, complete inhibition at 10 mM 21 2.3.1.39 iodoacetamide malonyl-CoA protects; pH-dependent 67 2.3.1.39 iodoacetamide - 67 2.3.1.39 iodoacetamide 59% inhibition at 0.1 mM 67 2.3.1.39 iodoacetate - 93 2.3.1.39 isoniazid acts synergistically with trifluoroperazine 851 2.3.1.39 magnoflorine - 151088 2.3.1.39 malonyl-CoA inhibition of MCT1 at 0.01 mM and inhibition of both isozymes at 0.02 mM and 0.04 mM; inhibits both MCT1 and MCT2 76 2.3.1.39 methylmalonyl-CoA inhibition of MCT1 at 0.1 mM 790 2.3.1.39 MgCl2 1 mM, 34% inhibition 196 2.3.1.39 MnCl2 1 mM, 7% inhibition 307 2.3.1.39 additional information - 2 2.3.1.39 additional information arsenite 2 2.3.1.39 additional information inhibition of the enzyme by thiol-alkylating reagents 2 2.3.1.39 additional information no inhibition by sulfhydryl inhibitors 2 2.3.1.39 additional information apparently homogeneous enzyme not inhibited by sulfhydryl agents, N-ethylmaleimide and iodoacetamide, highly purified enzyme stimulated by dithiothreitol 2 2.3.1.39 additional information inhibition of malonyl-enzyme intermediate formation by p-chloromercuribenzoate, reversible by 2-mercaptoethanol, prevented by preincubation with malonyl-CoA; inhibition of malonyl-enzyme intermediate formation by phenylmethanesulfonyl fluoride, malonyl-CoA protects; pH-dependent inhibition of malonyl-enzyme intermediate formation by N-ethylmaleimide 2 2.3.1.39 additional information pH-dependent inhibition of malonyl-enzyme intermediate formation by N-ethylmaleimide 2 2.3.1.39 N-ethylmaleimide 79% inhibition at 0.1 mM 49 2.3.1.39 N-ethylmaleimide malonyl-CoA protects; pH-dependent inhibition of purified enzyme 49 2.3.1.39 N-ethylmaleimide - 49 2.3.1.39 N-ethylmaleimide 1 mM, isozyme MCT2: 40% loss of activity of isozyme MCT2, no effect on isozyme MCT1, both, MCT1 and MCT2, are inactivated at 10 mM 49 2.3.1.39 NiSO4 1 mM, 12% inhibition 2860 2.3.1.39 p-chloromercuribenzoate pH-independent 43 2.3.1.39 p-chloromercuribenzoate strong 43 2.3.1.39 p-toluenesulfonyl fluoride strong inhibitor 111624 2.3.1.39 phenylmethanesulfonyl fluoride malonyl-CoA protects 827 2.3.1.39 phenylmethanesulfonyl fluoride - 827 2.3.1.39 phenylmethanesulfonyl fluoride not inhibitory 827 2.3.1.39 propionyl-CoA inhibition of both isozymes at 0.1 mM 350 2.3.1.39 reduced CoA inhibition of both isozymes at 0.1 mM 31068 2.3.1.39 succinyl-CoA inhibition of MCT2 at 0.02 mM and inhibition of both isozymes at 0.1 mM 224 2.3.1.39 sulfhydryl compounds - 1771 2.3.1.39 sulfhydryl compounds purified enzyme 1771 2.3.1.39 Trifluoperazine - 977 2.3.1.39 trifluoroperazine acts as calmodulin-antagonist in animals, inhibits mycobacterial lipid synthesis, acts synergistically with isoniazid 6813