1.1.1.3 L-threonine the enzyme activity is subjected to feedback regulation by L-threonine 250 1.1.1.3 L-threonine the natural threonine binding sites of the enzyme are predicted and verified by mutagenesis experiments 250 1.1.1.3 L-threonine allosteric inhibitor 250 1.1.1.3 L-valyl-5-hydroxy-4-oxo-L-norvaline i.e. (S)-2-N-[(S)-valyl]amino-5-hydroxy-4-oxopentanoic acid 255944 1.1.1.3 lysine - 1107 1.1.1.3 methionine - 692 1.1.1.3 methionine weakly inhibits reverse but not forward reaction 692 1.1.1.3 additional information no inhibition by [2-(1,1-dimethylethyl)-4-[[5-(1,1-dimethylethyl)-4-hydroxy-2-methylphenyl]thio]-5-methylphenoxy]-acetic acid and 4-amino-butyric acid 2-tert-butyl-4-(3-tert-butyl-4-hydroxy-phenylsulfanyl)-phenyl ester 2 1.1.1.3 additional information Thr does not inhibit homoserine dehydrogenase 1 2 1.1.1.3 additional information Lys, Met, and S-2-aminoethyl-L-cysteine do not affect HSDH activity at 1-5 mM 2