2.2.1.1	benfotiamine	-	695145	
2.2.1.1	benfotiamine	not inhibitory on proliferation of insulinoma cell line INS-1. Treatment activates glucose metabolism in INS-1 cells in high-glucose culture conditions and maximizes the cells' ability to synthesize insulin. Treatment activates glucokinase	695145	
2.2.1.1	cysteine	activation, 10 mM	486006	
2.2.1.1	ethanol	activation, 1-10% v/v	486006	
2.2.1.1	hydrogen peroxide	oxidative stress increases tktA expression. Induces tktA at 1 h treatment, while an increase in marRAB operon expression occurs only after 3 h exposure	694217	
2.2.1.1	additional information	active centers of the enzyme are functionally nonequivalent with respect to ribose 5-phosphate binding	690697	
2.2.1.1	additional information	highest productivity unter slightly aerobic conditions	704746	
2.2.1.1	additional information	increased levels of TKTL1 transcript in tumors compared with their corresponding normal tissues. Positive correlation between TKTL1 protein expression in primary tumors and the number of metastatic lymph-nodes as well as the diameter of the largest metastatic area in lymph-nodes. High levels of TKTL1 transcript are a relevant phenomenon in small PTCs	691583	
2.2.1.1	additional information	positive transcriptional regulation of the talA-tktB operon by ppGpp	694236	
2.2.1.1	additional information	positive transcriptional regulation of the talA-tktB operon by ppGpp. Activation of tktB transcription by ppGpp occurs both through the modulation of RpoS levels and independent of RpoS	694236