2.1.1.204	additional information	the presence of the nucleotide queuosine (Q) in tRNAAsp strongly stimulates Dnmt2 activity both in vivo and in vitro. Queuine, the respective base, is a hypermodified guanine analogue that is synthesized from guanosine-5'-triphosphate (GTP) by bacteria. Most eukaryotes have queuosine in their tRNA. However, they cannot synthesize it themselves, but rather salvage it from food or from gut microbes. The queuine obtained from these sources comes from the breakdown of tRNAs, where the queuine ultimately is synthesized by bacteria. Queuine thus has been termed a micronutrient	756159	
2.1.1.204	queuine	a micronutrient that is scavenged by higher eukaryotes from the diet and gut microflora. The enzyme is strongly stimulated by prior queuosine modification of the substrate tRNA. In vivo tRNA methylation levels are stimulated by growth of cells in queuine-containing medium	736905