2.8.2.15	celecoxib	heterotrophic modulator, switches sulfation from the 3-O-position to the 17beta-O-position and activates such that the total sulfated product exceed product formation by the native enzyme, 3fold to 4fold at 0.25 mM celecoxib	661577	
2.8.2.15	additional information	enzyme induction by 1alpha,25-dihydroxyvitamin D3 via the vitamin D responsive element C/ERB-alpha, but not C/ERB-beta, coactivators p300, steroid receptor coactivator 1 and 2, SRC-1 and SRC-2, but not SRC-3, are also required, overview	675998	
2.8.2.15	additional information	induction of SULT2A1 expression by xenobiotic-activated nuclear receptors pregnane X receptor PXR, constitutive androstane receptor CAR, and the vitamin D3-activated nuclear receptor VDR, aging has no effect on the activity of an IR0 enhancer in the Sult2A1 chromatin to recruit VDR, RXR-alpha, and PXR in mice injected with D3 or PCN	673838	
2.8.2.15	additional information	lithocholic acid induces SULT2A in wild-type and farnesoid X receptor-null mice, chenodeoxycholic acid induces the enzyme only in farnesoid X receptor-null mice, not in wild-type mice, overview	673311	
2.8.2.15	additional information	methotrexate induces SULT2A1 expression via nuclear receptor interactions, molecular mechanism, overview, the constitutive active receptor, CAR, mediates the methotrexate induction of SULT2A1 in both Caco-2 and Hep G2 cells, vitamin D receptor, VDR, also upregulates SULT2A1 gene expression, CAR inhibits VDR-mediated vitaminD3 induction of SULT2A1 but notmethotrexate induction of SULT2A1, overview	674394	
2.8.2.15	additional information	SULT2A1 is a target gene for metabolic regulation/induction by thyroid hormone T3, T3 overexpressing cell s show increased SULT2A1 expression, indirect regulation mechanism via the transcription factor steroidogenic factor 1, SF1, overview	673350	
2.8.2.15	additional information	the enzyme promoter contains composite elements inducible by nuclear receptors pregnane X receptor and constitutive androstane receptor, synergizing effects by HNF4alpha binding at a site near the promoter, overview	676007