1.14.99.1	5-hydroxytryptamine	stimulates	438389	
1.14.99.1	arachidonate	-	716959	
1.14.99.1	arachidonic acid	exogenous, increases hPHS activity	715090	
1.14.99.1	benzoquinone	stimulates conversion of prostaglandin G1 to H1	438375	
1.14.99.1	cysteine	stimulates	438389	
1.14.99.1	dopamine	-	438392	
1.14.99.1	dopamine	3,4-dihydroxyphenylethylamine, stimulates	438389	
1.14.99.1	ellagic acid	at high concentration and in presence of cofactors inhibition, at low concentrations stimulation	438370	
1.14.99.1	epinephrine	-	438391, 438392	
1.14.99.1	epinephrine	stimulates conversion of prostaglandin G1 to H1	438375	
1.14.99.1	glutathione	promotes prostaglandin H synthase-dependent formation of oxidative stress biomarkers malondialdehyde and 15(S)-8-iso-prostaglandin F2alpha	727520	
1.14.99.1	hemin	activates	438374	
1.14.99.1	hydroperoxyeicosatetraenoic acid	-	438371	
1.14.99.1	hydroquinone	-	438391	
1.14.99.1	hydroquinone	stimulates conversion of prostaglandin G1 to H1	438375	
1.14.99.1	indole	stimulates conversion of prostaglandin G1 to H1	438375	
1.14.99.1	kynurenine	stimulates conversion of prostaglandin G1 to H1	438375	
1.14.99.1	Melatonin	-	438389	
1.14.99.1	Melatonin	stimulates	438375	
1.14.99.1	additional information	aqueous extracts of Chromoleana odorata, commonly used in traditional medicine as antiinflammatory drug against pains or as cataplasm to stop hemorrhage in Ivory Coast, the essential oil extracted from the fresh leaves activates the cyclooxygenase activity of the PGHS, overview	713706	
1.14.99.1	additional information	cyclooxygenase catalysis by prostaglandin H synthase-1 and -2 requires activation of the normally latent enzyme by peroxide-dependent generation of a free radical at Tyr385 (PGHS-1 numbering) in the cyclooxygenase active site. The Tyr385 radical has also been linked to self-inactivation processes that impose an ultimate limit on cyclooxygenase catalysis	659392	
1.14.99.1	additional information	hypoxia and glucose-free medium treatment synergistically increase PGHS-2 mRNA approximately 8fold	672839	
1.14.99.1	additional information	oxygen and glucose depivation induce PGHS-2 gene expression synergistically in neurons	672839	
1.14.99.1	additional information	stimulation of enzyme in crude extract by some amines	438392	
1.14.99.1	additional information	the enzyme is induced by arachidonic acid up to 7.5-fold within 6 h, it is also induced by protein kinase C activators 4beta-PMA and PGF2alpha, all activation effects are blocked by PKC inhibitors, regulation, overview, protein kinase C induces PTGS2 independently of PPARs, i.e. peroxisome-proliferator-activated receptors	684980	
1.14.99.1	additional information	USF proteins are involved in the trans-activation of the PGH-2 promoter in granulosa cells	659436	
1.14.99.1	norepinephrine	-	438392	
1.14.99.1	Oestrogens	weak stimulation	438389	
1.14.99.1	peroxynitrite	peroxidase activity, MS-analysis reveals that tyrosine 385 is a target for nitration by ONOO- only when heme is present	675273	
1.14.99.1	phenylalanine	stimulates conversion of prostaglandin G1 to H1	438375	
1.14.99.1	quinol	stimulates	438389	
1.14.99.1	reduced glutathione	stimulates	438389	
1.14.99.1	serotonin	-	438391	
1.14.99.1	serotonin	stimulates conversion of prostaglandin G1 to H1	438375	
1.14.99.1	Tannic acid	at high concentration and in presence of cofactors inhibition, at low concentrations stimulation	438370	
1.14.99.1	Thyroid hormones	weak stimulation	438389	
1.14.99.1	thyrotropin	tissue-specific stimulation in thyroid	438390	
1.14.99.1	tryptophan	stimulates conversion of prostaglandin G1 to H1	438375	
1.14.99.1	tyrosine	stimulates conversion of prostaglandin G1 to H1	438375