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Version 2014-12-22
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Details for neuromuscular junction
neuromuscular junction
Gene ontology ID
GO:0031594
Definition
The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential
Comment
In vertebrates, the term 'neuromuscular junction' is limited to synapses targeting skeletal muscle fibers - all of which are cholinergic and excitatory. Both inhibitory and excitatory neuromuscular junctions exist in invertebrates, utilizing a range of neurotransmitters including glutamate, GABA and 5-HT.
Synonyms
1. motor endplate
2. NMJ
References
1. GOC: nln
2. NIF Subcellular: sao1124888485
3. Wikipedia: Neuromuscular junction
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