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Gene ontology
Version 2014-12-22
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Details for mediator complex
mediator complex
Gene ontology ID
GO:0016592
Definition
A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins
Synonyms
1. CDK8-containing TRAP/mediator complex
2. L mediator complex
3. Srb-mediator complex
4. TRAP complex
References
1. PMID 11454195
2. PMID 16168358
3. PMID 17870225
4. Wikipedia: Mediator (coactivator)
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is an element of the parent element
is a part of the parent element
is related to the parent element
derives from the parent element
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