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BRENDA support

Ontology explorer

Gene ontology
Version 2014-12-22
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Details for MKS complex
Gene ontology ID
GO:0036038
Definition
A protein complex that is located at the ciliary transition zone and consists of several proteins some of which are membrane bound. Acts as an organiser of transition zone inner structure, specifically the Y-shaped links, in conjunction with the NPHP complex. The MKS complex also acts as part of the selective barrier that prevents diffusion of proteins between the ciliary cytoplasm and cellular cytoplasm as well as between the ciliary membrane and plasma membrane
Comment
Although there is some evidence, it is still unclear if the MKS and NPHP complexes are constituents parts of the Y-shaped links or are simply responsible for aligning and attaching the Y-shaped links to the membrane and axoneme.
Synonyms
1. B9 complex
2. MKS module
3. TCTN-B9D complex
4. tectonic complex
5. tectonic-like complex
References
1. GOC: cilia
2. GOC: sp
3. PMID 21422230
4. PMID 21565611
5. PMID 21725307
6. PMID 22179047
7. PMID 25869670
8. PMID 26595381
9. PMID 26982032
Legend
is an element of the parent element
is a part of the parent element
is related to the parent element
derives from the parent element
// at least 1 tissue/ enzyme/ localization link in this branch
// tissue/ enzyme/ localization link to BRENDA
Condensed Tree View
Gene ontology
cellular_component is a
cellular anatomical entity is a
cell periphery is a651 BRENDA localization in branch, click for list of all
plasma membrane part of611 BRENDA localization in branch, click for list of all
plasma membrane region part of
plasma membrane bounded cell projection
cilium is a34 BRENDA localization in branch, click for list of all
ciliary transition zone part of
MKS complex part of