Gene ontology ID
GO:1990455
Definition
A phospholipid phosphatase complex that catalyses the hydrolysis of the second messenger PtdIns (3,4,5)P3. Will also dephosphorylate PtdIns(3,4)P2, PtdIns3P, and Ins(1,3,4,5)P4. Dimerization is critical for its lipid phosphatase function
Comment
An example of this is PTEN in human (P60484) in PMID:24766807 (inferred from direct assay).
Synonyms
1. phosphatase and tensin homolog
2. phosphatase and tensin homolog deleted on chromosome ten homodimer
3. phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN homodimer
References
1. GOC: bhm
2. PMID 247668073. IntAct: EBI-9637198
4. IntAct: EBI-9637224
Legend
is an element of the parent element
is a part of the parent element
is related to the parent element
derives from the parent element
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at least 1 tissue/ enzyme/ localization link in this branch
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tissue/ enzyme/ localization link to BRENDA