Ontology explorer

Gene ontology
Version 2014-12-22
use AND (NOT) or OR
use AND (NOT) or OR
restrict to BRENDA links:
2 different search results found

Details for HSP90-CDC37 chaperone complex
Gene ontology ID
A protein complex involved in stress-induced mitophagy (mitochondrial degradation). In mammals it consists of heat shock protein HSP90 and its co-chaperone CDC37. Experimental evidence suggests that the complex enables the autophosphorylation of ULK1. Phosphorylated ULK1 in turn phosphorylates ATG13 which is an essential step in mitophagy. HSP90-CDC37 binding prevents rapid ubiquitin-dependent proteosomal degradation of its targets
An example of this is HSP90AB1 in human (UniProt symbol P08238) in PMID:21855797 (inferred from direct assay).
1. GOC: bhm
2. IntAct: EBI-9990131
3. IntAct: EBI-9990540
4. PMID 21855797
5. PMID 22939624
is an element of the parent element
is a part of the parent element
is related to the parent element
derives from the parent element
// at least 1 tissue/ enzyme/ localization link in this branch
// tissue/ enzyme/ localization link to BRENDA
Condensed Tree View
Gene ontology
Tree view
Gene ontology