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Gene ontology
Version 2014-12-22
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Details for HSP90-CDC37 chaperone complex
Gene ontology ID
GO:1990565
Definition
A protein complex involved in stress-induced mitophagy (mitochondrial degradation). In mammals it consists of heat shock protein HSP90 and its co-chaperone CDC37. Experimental evidence suggests that the complex enables the autophosphorylation of ULK1. Phosphorylated ULK1 in turn phosphorylates ATG13 which is an essential step in mitophagy. HSP90-CDC37 binding prevents rapid ubiquitin-dependent proteosomal degradation of its targets
Comment
An example of this is HSP90AB1 in human (UniProt symbol P08238) in PMID:21855797 (inferred from direct assay).
References
1. GOC: bhm
2. IntAct: EBI-9990131
3. IntAct: EBI-9990540
4. PMID 21855797
5. PMID 22939624
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