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Gene ontology
Version 2014-12-22
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Details for PTEN phosphatase complex
Gene ontology ID
GO:1990455
Definition
A phospholipid phosphatase complex that catalyses the hydrolysis of the second messenger PtdIns (3,4,5)P3. Will also dephosphorylate PtdIns(3,4)P2, PtdIns3P, and Ins(1,3,4,5)P4. Dimerization is critical for its lipid phosphatase function
Comment
An example of this is PTEN in human (P60484) in PMID:24766807 (inferred from direct assay).
Synonyms
1. phosphatase and tensin homolog
2. phosphatase and tensin homolog deleted on chromosome ten homodimer
3. phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN homodimer
References
1. GOC: bhm
2. PMID 24766807
3. IntAct: EBI-9637198
4. IntAct: EBI-9637224
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Gene ontology
cellular_component is a
protein-containing complex is a50 BRENDA localization in branch, click for list of all
catalytic complex is a48 BRENDA localization in branch, click for list of all
phosphatase complex is a8 BRENDA localization in branch, click for list of all
phosphatidylinositol phosphate phosphatase complex is a
PTEN phosphatase complex is a