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Version 2014-12-22
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Details for RSP5-BUL ubiquitin ligase complex
Gene ontology ID
GO:1990306
Definition
A ubiquitin ligase complex consisting of RSP5 and BUL components. It polyubiquinates plasma membrane transporters and permeases, required for their endocytosis and subsequent degradation in the vacuole. BUL1 or BUL2, respectively, bind to the target protein, enabling ubiquitylation by Rsp5. Phosphorylation of BUL proteins results in binding to 14-3-3 proteins, protecting the permeases from down-regulation
Comment
This complex has been identified in Saccharomyces cerevisiae (P19812) - see PMID:9931424
References
1. GOC: bhm
2. IntAct: EBI-9105217
3. IntAct: EBI-9105295
4. PMID 9931424
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