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Gene ontology
Version 2014-12-22
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Details for platelet-derived growth factor receptor-ligand complex
Gene ontology ID
GO:1990270
Definition
A tetrameric protein complex consisting of two platelet-derived growth factor (PDGF) receptor subunits and two PDGF ligand subunits. Binding of the PDGF ligand dimer to the PDGF receptor in the plasma membrane induces receptor dimerisation and activation. PDGFs are involved in a wide variety of signalling processes and are found in all vertebrates. At least two different receptor chains (A and B) and four types of ligand chains (A, B, C, and D) are known forming a wide variety of combinations of receptor-ligand complexes
Comment
An example of this is PDGFA-PGFRA in human (UniProt symbols P04085, P16234) in PMID:7679113 (inferred from direct assay).
Synonyms
1. PDGF complex
2. PDGF receptor-ligand complex
3. PDGF-AA-receptor alpha complex
4. PDGF-AB-receptor alpha complex
5. PDGF-AB-receptor beta complex
6. PDGF-BB-receptor alpha complex
7. PDGF-BB-receptor alpha-beta complex
8. PDGF-BB-receptor beta complex
9. PDGF-CC-receptor alpha complex
10. PDGF-CC-receptor alpha-beta complex
11. PDGF-CC-receptor beta complex
12. PDGF-DD-receptor alpha-beta complex
13. PDGF-DD-receptor beta complex
14. receptor-ligand complex
References
1. GOC: bhm
2. PMID 11331882
3. IntAct: EBI-9080360
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