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Gene ontology
Version 2014-12-22
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Details for STING complex
Gene ontology ID
GO:1990231
Definition
A protein dimer containing two STING monomers. It binds cyclic purine di-nucleotides. Activation of the sting complex by 2',5'-3'-5'-cyclic GMP-AMP activates nuclear transcription factor kB (NF-kB) and interferon regulatory factor 3 (IRF3) which then induce transcription of the genes encoding type I IFN and cytokines active in the innate immune response
Synonyms
1. stimulator of interferon genes complex
References
1. GOC: bhm
2. PMID 22705373
3. PMID 23706668
4. PMID 23910378
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Gene ontology