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Version 2014-12-22
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Details for macrolide transmembrane transporter complex
Gene ontology ID
GO:1990195
Definition
A bacterial transmembrane transporter complex that spans the entire cell membrane system and possesses ATP-dependent xenobiotic transport activity pumping drugs (typically antibiotics) and other toxins directly from the cytosol out of the bacterial cell. Typically, it is trimeric consisting of a inner membrane ATPase (IMP), a periplasmic membrane fusion protein (MFP) and an outer membrane factor (OMF). In E. coli, macrolide transporter complexes may consists of MacB (IMP), MacA (MFP) and TolC (OMF) or AcrB (IMP), AcrA (MFP) and TolC (OMF). Trimeric TolC is a common OMF found in many macrolide transporter complexes
Synonyms
1. AcrAB-TolC complex
2. MacAB-TolC complex
3. macrolide transporter
4. macrolide transporter complex
References
1. GOC: bhm
2. PMID 10879525
3. PMID 18955484
4. PMID 19254725
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