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Version 2014-12-22
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Details for GAIT complex
Gene ontology ID
GO:0097452
Definition
A protein complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. The complex binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs and suppresses their translation by blocking the recruitment of the 43S ribosomal complex to m7G cap-bound eIF4G. In humans it includes RPL13A, EPRS, SYNCRIP and GAPDH; mouse complexes lack SYNCRIP
Synonyms
1. gamma interferon-activated inhibitor of translation complex
2. IFN-gamma-activated inhibitor of translation complex
References
1. GOC: br
2. PMID 15479637
3. PMID 23071094
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Gene ontology