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Version 2014-12-22
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Details for PAS complex
Gene ontology ID
GO:0070772
Definition
A class III phosphatidylinositol 3-kinase complex that contains a phosphatidylinositol-3-phosphate 5-kinase subunit (Fab1p in yeast; PIKfyve in mammals), a kinase activator, and a phosphatase, and may also contain additional proteins; it is involved in regulating the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate. In mammals the complex is composed of PIKFYVE, FIG4 and VAC14. In yeast it is composed of Atg18p, Fig4p, Fab1p, Vac14p and Vac7p
Synonyms
1. autophagy-specific phosphatidylinositol 3-kinase complex
References
1. PMID 18950639
2. PMID 19037259
3. PMID 19158662
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