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Gene ontology
Version 2014-12-22
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Details for gamma-secretase complex
gamma-secretase complex
Gene ontology ID
GO:0070765
Definition
A protein complex that has aspartic-type endopeptidase activity, and contains a catalytic subunit, presenilin (PS), that is a prototypical member of the GxGD-type aspartyl peptidases. The complex also contains additional subunits, including nicastrin, APH-1, PEN-2, and a regulatory subunit, CD147. Gamma-secretase cleaves several transmembrane proteins including the cell surface receptor Notch and the beta-amyloid precursor protein
References
1. GOC: mah
2. PMID 15286082
3. PMID 15890777
4. PMID 17047368
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