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Version 2014-12-22
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Details for gamma-secretase complex
gamma-secretase complex
Gene ontology ID
GO:0070765
Definition
A protein complex that has aspartic-type endopeptidase activity, and contains a catalytic subunit, presenilin (PS), that is a prototypical member of the GxGD-type aspartyl peptidases. The complex also contains additional subunits, including nicastrin, APH-1, PEN-2, and a regulatory subunit, CD147. Gamma-secretase cleaves several transmembrane proteins including the cell surface receptor Notch and the amyloid-beta precursor protein
Synonyms
1. CD147-gamma-secretase complex (APH-1a, PS-1, PEN-2, NCT variant)
2. gamma-secretase complex (APH1A, PSEN1, PSENEN, NCSTN variant)
3. gamma-secretase complex (APH1A, PSEN2, PSENEN, NCSTN)
4. gamma-secretase complex (APH1B, PSEN1, PSENEN, NCSTN)
5. gamma-secretase complex (APH1B, PSEN2, PSENEN, NCSTN)
References
1. GOC: mah
2. PMID 15286082
3. PMID 15890777
4. PMID 17047368
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