Any feedback?
Please rate this page
(ontology.php)
(0/150)

BRENDA support

Ontology explorer

Gene ontology
Version 2014-12-22
use AND (NOT) or OR
use AND (NOT) or OR
restrict to BRENDA links:
Details for gamma-secretase complex
gamma-secretase complex
Gene ontology ID
GO:0070765
Definition
A protein complex that has aspartic-type endopeptidase activity, and contains a catalytic subunit, presenilin (PS), that is a prototypical member of the GxGD-type aspartyl peptidases. The complex also contains additional subunits, including nicastrin, APH-1, PEN-2, and a regulatory subunit, CD147. Gamma-secretase cleaves several transmembrane proteins including the cell surface receptor Notch and the amyloid-beta precursor protein
Synonyms
1. CD147-gamma-secretase complex (APH-1a, PS-1, PEN-2, NCT variant)
2. gamma-secretase complex (APH1A, PSEN1, PSENEN, NCSTN variant)
3. gamma-secretase complex (APH1A, PSEN2, PSENEN, NCSTN)
4. gamma-secretase complex (APH1B, PSEN1, PSENEN, NCSTN)
5. gamma-secretase complex (APH1B, PSEN2, PSENEN, NCSTN)
References
1. GOC: mah
2. PMID 15286082
3. PMID 15890777
4. PMID 17047368
Legend
is an element of the parent element
is a part of the parent element
is related to the parent element
derives from the parent element
// at least 1 tissue/ enzyme/ localization link in this branch
// tissue/ enzyme/ localization link to BRENDA
Condensed Tree View
Gene ontology