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Gene ontology
Version 2014-12-22
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Details for RISC-loading complex
Gene ontology ID
GO:0070578
Definition
A trimeric protein complex required for the formation of a mature RNA-induced silencing complex (RISC). In humans the complex is composed of the endonuclease Dicer (DICER1), TRBP (TARBP2) and the Argonaute protein Ago2 (EIF2C2/AGO2). Within the complex, Dicer and TRBP are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto Ago2. Ago2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from Dicer and TRBP. This complex has endoribonuclease activity
Synonyms
1. microRNA loading complex
2. miRLC
3. RLC
References
1. GOC: ab
2. GOC: BHF
3. GOC: nc
4. GOC: rph
5. PMID 18178619
6. PMID 19820710
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