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Version 2014-12-22
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Details for nuclear pore central transport channel
Gene ontology ID
GO:0044613
Definition
The central substructure of the nuclear pore complex (NPC), through which nucleocytoplasmic transport of RNAs, proteins and small molecules occurs. The central transport channel is filled with FG-nucleoporins, which form a selective barrier and provide a series of binding sites for transporter proteins. Characterized S. cerevisiae FG-nucleoporins include Nup159p, Nup145Np, Nup116p, Nup100p, Nsp1p, Nup57p, Nup49p, Nup42p, Nup53p, Nup59p/Asm4p, Nup60p and Nup1. Characterized vertebrate FG-nucleoporins include Nup214, Nup98, Nup62, Nup54, Nup58/45, NLP1, and Nup153
Synonyms
1. karyopherin docking complex
2. nuclear pore central channel
3. nuclear pore central plug
4. nuclear pore transport channel
References
1. GOC: dgf
2. PMID 18046406
3. PMID 19524430
4. PMID 20947011
5. PMID 22419078
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