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Version 2014-12-22
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Details for MHC class I peptide loading complex
Gene ontology ID
GO:0042824
Definition
A large, multisubunit complex which consists of the MHC class I-beta 2 microglobulin dimer, the transporter associated with antigen presentation (TAP), tapasin (an MHC-encoded membrane protein), the chaperone calreticulin and the thiol oxidoreductase ERp57. Functions in the assembly of peptides with newly synthesized MHC class I molecules
Comment
Note that although this complex is located in the endoplasmic reticulum, there is some evidence that it may also be found in the Golgi.
Synonyms
1. peptide-loading complex
2. PLC
References
1. GOC: jl
2. PMID 10631934
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Gene ontology