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Version 2014-12-22
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Details for VCP-NPL4-UFD1 AAA ATPase complex
Gene ontology ID
GO:0034098
Definition
A multiprotein ATPase complex required for the efficient dislocation of ER-lumenal degradation substrates, and their subsequent proteolysis by the proteasome. In budding yeast, this complex includes Cdc48p, Npl4p and Ufd1p proteins. In mammals, this complex includes a hexamer of VCP/p97 (a cytosolic ATPase) and trimers of each of its cofactors UFD1L and NPL4 (NPLOC4) (e.g. a 6:3:3 stoichiometry)
Synonyms
1. Cdc48p-Npl4p-Ufd1p AAA ATPase complex
2. p97-Ufd1-Npl4 complex
References
1. PMID 11813000
2. PMID 16179952
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