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Version 2014-12-22
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Details for cyclin-dependent protein kinase activating kinase holoenzyme complex
Gene ontology ID
GO:0019907
Definition
A cyclin-dependent kinase activating kinase complex capable of activating cyclin-dependent kinases by threonine phosphorylation, thus regulating cell cycle progression. consists of a kinase, cyclin and optional assembly factors, in human CDK7, CCNH and MNAT1. CAK activity is itself regulated throughout the cell cycle by T-loop phosphorylation of its kinase component (CDK7 in human). Phosphorylation of serine residues during mitosis inactivates the enzyme. Also capable of CAK phosphorylating the carboxyl-terminal domain (CTD) of RNA polymerase II and other transcription activating proteins, as part of the general transcription factor TFIIH
Synonyms
1. CAK complex
2. CDK-activating kinase complex
References
1. GOC: bhm
2. PMID 8752210
3. IntAct: EBI-1246076
4. IntAct: EBI-9868598
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