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Version 2014-12-22
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Details for IkappaB kinase complex
IkappaB kinase complex
Gene ontology ID
GO:0008385
Definition
A trimeric protein complex that phosphorylates inhibitory-kappaB (I-kappaB) proteins. The complex is composed of two kinase subunits (alpha and beta) and a regulatory gamma subunit (also called NEMO). In a resting state, NF-kappaB dimers are bound to inhibitory IKB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription
Synonyms
1. heterotrimeric IKK complex
2. IKK complex
3. trimeric IKK complex
References
1. GOC: bf
2. GOC: ma
3. PMID 12055104
4. PMID 20300203
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