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Gene ontology
Version 2014-12-22
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Details for exosome (RNase complex)
Gene ontology ID
GO:0000178
Definition
A ribonuclease complex that has 3-prime to 5-prime exoribonuclease activity and possibly endoribonuclease activity, producing 5-prime-phosphomonoesters. Participates in a multitude of cellular RNA processing and degradation events preventing nuclear export and/or translation of aberrant RNAs. Restricted to processing linear and circular single-stranded RNAs (ssRNA) only. RNAs with complex secondary structures may have to be unwound or pre-processed by co-factors prior to entering the complex, esp if the 3-prime end is structured
Comment
Note that this term should not be confused with 'exosome' used in the context of vesicles released from multivesicular bodies.
Synonyms
1. exosome (ribonucleasease complex)
2. exosome multienzyme ribonuclease complex
References
1. PMID 17174896
2. PMID 20531386
3. PMID 26726035
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