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Version 2014-12-22
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Details for PTEN phosphatase complex
Gene ontology ID
GO:1990455
Definition
A phospholipid phosphatase complex that catalyses the hydrolysis of the second messenger PtdIns (3,4,5)P3. Will also dephosphorylate PtdIns(3,4)P2, PtdIns3P, and Ins(1,3,4,5)P4. Dimerization is critical for its lipid phosphatase function
Comment
An example of this is PTEN in human (P60484) in PMID:24766807 (inferred from direct assay).
Synonyms
1. phosphatase and tensin homolog
2. phosphatase and tensin homolog deleted on chromosome ten homodimer
3. phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN homodimer
References
1. GOC: bhm
2. PMID 24766807
3. IntAct: EBI-9637198
4. IntAct: EBI-9637224
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