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Gene ontology
Version 2014-12-22
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Details for interferon regulatory factor complex
Gene ontology ID
GO:0097071
Definition
A protein complex that consists of two interferon regulatory proteins (IRFs); may be homodimeric or heterodimeric. The activation of a latent closed conformation of IRF in the cytoplasm is triggered by phosphorylation of Ser/Thr residues in a C-terminal region. Phosphorylation stimulates the C-terminal autoinhibitory domain to attain a highly extended conformation triggering dimerization through extensive contacts to a second subunit
Synonyms
1. IRF complex
References
1. GOC: cna
2. PMID 20043992
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