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Gene ontology
Version 2014-12-22
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Details for PRC1 complex
PRC1 complex
Gene ontology ID
GO:0035102
Definition
A multiprotein complex that mediates monoubiquitination of lysine residues of histone H2A (lysine-118 in Drosophila or lysine-119 in mammals). The complex is required for stable long-term maintenance of transcriptionally repressed states and is involved in chromatin remodeling
Comment
In Drosophila the core subunits are Pc (Polycomb), Psc (Posterior sex combs), Ph (Polyhomeotic) and Sce (Sex comb extra). In mammals, which have several orthologs for each of the Drosophila core proteins, a family of distinct PRC1-like complexes seem to exist which contain at least some PcG proteins in mutually exclusive manner.
Synonyms
1. Polycomb repressive complex 1
References
1. GOC: bf
2. PMID 10412979
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