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Ontology explorer

Gene ontology
Version 2014-12-22
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Details for NURS complex
Gene ontology ID
GO:1990477
Definition
The nuclear RNA silencing (NURS) complex is a protein complex formed by an RNA binding protein Red1, an RNA helicase Mtl1, Red5, Rmn1, Iss10/Pir1, and Ars2/Pir2. This complex is required for the recruitment of the nuclear exosome to Mmi1 nuclear focus. It is likely related to the human CBCN complex. This complex is also known as MTREC
Comment
An example of this is the complex formed by Red1 and Mtl1 in S. pombe (UniProt symbols Q9UTR8 and O13799 respectively) in PMID:24210919 (inferred from direct assay).
Synonyms
1. Mtl1-Red1 core complex
2. MTREC complex
References
1. PMID 24210919
2. PMID 24713849
3. PMID 32012158
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