Ontology explorer

Gene ontology
Version 2014-12-22
use AND (NOT) or OR
use AND (NOT) or OR
restrict to BRENDA links:
23 different search results found


Details for heteromeric SMAD protein complex
Gene ontology ID
GO:0071144
Definition
A protein complex composed of SMAD family proteins, a transcription factor complex which binds to the promoters of target genes and recruits co-activators and histone acetyltransferases, facilitating transcription. Phosphorylation of the non-SMAD4 subunit(s) enables binding of SMAD4 to form heteromeric complexes that enter the nucleus to initiate gene transcription. DNA-binding specificity is conferred by other transcription factors binding to SMAD complexes. Interactions with coactivators or corepressors modulate their transcriptional activity. Can be heterotrimeric or heterodimeric
Synonyms
1. SMAD1-SMAD4 protein complex
2. SMAD2-SMAD3-SMAD4 protein complex
3. SMAD2-SMAD4 protein complex
4. SMAD3-SMAD4 protein complex
References
1. GOC: bhm
2. GOC: mah
3. PMID 11779505
4. PMID 15350224
5. PMID 16322555
6. PMID 9389648
7. PMID 9670020
8. IntAct: EBI-10021614
9. IntAct: EBI-10043452
10. IntAct: EBI-10127301
11. IntAct: EBI-10828741
12. IntAct: EBI-9692430
13. IntAct: EBI-9826270
14. IntAct: EBI-9826300
15. IntAct: EBI-9990274
Legend
is an element of the parent element
is a part of the parent element
is related to the parent element
derives from the parent element
// at least 1 tissue/ enzyme/ localization link in this branch
// tissue/ enzyme/ localization link to BRENDA
Condensed Tree View
Gene ontology
Tree view
Gene ontology