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Gene ontology
Version 2014-12-22
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23 different search results found


Details for heteromeric SMAD protein complex
Gene ontology ID
GO:0071144
Definition
A protein complex composed of SMAD family proteins, a transcription factor complex which binds to the promoters of target genes and recruits co-activators and histone acetyltransferases, facilitating transcription. Phosphorylation of the non-SMAD4 subunit(s) enables binding of SMAD4 to form heteromeric complexes that enter the nucleus to initiate gene transcription. DNA-binding specificity is conferred by other transcription factors binding to SMAD complexes. Interactions with coactivators or corepressors modulate their transcriptional activity. Can be heterotrimeric or heterodimeric
Synonyms
1. SMAD1-SMAD4 protein complex
2. SMAD2-SMAD3-SMAD4 protein complex
3. SMAD2-SMAD4 protein complex
4. SMAD3-SMAD4 protein complex
References
1. GOC: bhm
2. GOC: mah
3. PMID 11779505
4. PMID 15350224
5. PMID 16322555
6. PMID 9389648
7. PMID 9670020
8. IntAct: EBI-10021614
9. IntAct: EBI-10043452
10. IntAct: EBI-10127301
11. IntAct: EBI-10828741
12. IntAct: EBI-9692430
13. IntAct: EBI-9826270
14. IntAct: EBI-9826300
15. IntAct: EBI-9990274
Legend
is an element of the parent element
is a part of the parent element
is related to the parent element
derives from the parent element
// at least 1 tissue/ enzyme/ localization link in this branch
// tissue/ enzyme/ localization link to BRENDA
Condensed Tree View
Gene ontology
cellular_component is a
cellular anatomical entity is a
organelle is a99 BRENDA localization in branch, click for list of all
intracellular organelle is a88 BRENDA localization in branch, click for list of all
intracellular membrane-bounded organelle is a
nucleus is a22 BRENDA localization in branch, click for list of all
germ cell nucleus is a
female germ cell nucleus is a
heteromeric SMAD protein complex part of
nuclear DNA-directed RNA polymerase complex part of
nuclear ubiquitin ligase complex part of
pronucleus is a8 BRENDA localization in branch, click for list of all
small nuclear ribonucleoprotein complex part of
spliceosomal snRNP complex is a
Tree view
Gene ontology
biological_process is a
cellular_component is a
cell is a
cellular anatomical entity is a
A band is a711 BRENDA localization in branch, click for list of all
acroblast is a
acrosomal matrix is a708 BRENDA localization in branch, click for list of all
actin body is a
actin cap is a707 BRENDA localization in branch, click for list of all
actin filament branch point is a
actin filament bundle is a
actin fusion focus is a
actin wave is a
actomyosin is a701 BRENDA localization in branch, click for list of all
actomyosin contractile ring, distal actin filament layer is a
actomyosin contractile ring, intermediate layer is a
actomyosin contractile ring, proximal layer is a
alae of collagen and cuticulin-based cuticle extracellular matrix is a
annular furrow extracellular matrix is a
annuli extracellular matrix is a
apical complex is a700 BRENDA localization in branch, click for list of all
apical cytoplasm is a
apical lamina of hyaline layer is a
apical part of cell is a695 BRENDA localization in branch, click for list of all
ascus epiplasm is a
assemblon is a
axon collateral is a693 BRENDA localization in branch, click for list of all
axon hillock is a692 BRENDA localization in branch, click for list of all
axon initial segment is a691 BRENDA localization in branch, click for list of all
axonemal basal plate is a
axonemal central apparatus is a
axonemal outer doublet is a
axoneme is a686 BRENDA localization in branch, click for list of all
bacterial biofilm matrix surface is a
bacterial-type flagellum basal body is a
bacterial-type flagellum filament is a
bacterial-type flagellum hook is a
bacterial-type flagellum hook-filament junction is a
basal labyrinth is a
basal layer of collagen and cuticulin-based cuticle extracellular matrix is a
basal part of cell is a
basolateral cytoplasm is a
bilobe structure is a
blood microparticle is a
Casparian strip is a
cell body is a681 BRENDA localization in branch, click for list of all
cell division site is a678 BRENDA localization in branch, click for list of all
cell junction is a673 BRENDA localization in branch, click for list of all
cell leading edge is a
cell periphery is a636 BRENDA localization in branch, click for list of all
cell plate is a466 BRENDA localization in branch, click for list of all
cell pole is a465 BRENDA localization in branch, click for list of all
cell projection is a
cell septum is a458 BRENDA localization in branch, click for list of all
cell surface is a457 BRENDA localization in branch, click for list of all
cell tip is a
cell trailing edge is a
cellular bud is a
central element is a455 BRENDA localization in branch, click for list of all
central plaque of spindle pole body is a
centriolar satellite is a
centrosomal corona is a
chiasma is a454 BRENDA localization in branch, click for list of all
chromatin is a453 BRENDA localization in branch, click for list of all
chromosomal region is a436 BRENDA localization in branch, click for list of all
cnida is a
compact myelin is a430 BRENDA localization in branch, click for list of all
concave side of sperm head is a
cone matrix sheath is a
contractile ring is a429 BRENDA localization in branch, click for list of all
cortical layer of collagen and cuticulin-based cuticle extracellular matrix is a
costamere is a
cytoophidium is a428 BRENDA localization in branch, click for list of all
cytoplasm is a427 BRENDA localization in branch, click for list of all
deep fiber is a
dense fibrillar component is a243 BRENDA localization in branch, click for list of all
dense nuclear body is a
dinoflagellate antapex is a
dinoflagellate apex is a
dinoflagellate epicone is a
dinoflagellate hypocone is a
DNA replication termination region is a
eisosome is a242 BRENDA localization in branch, click for list of all
endonuclear canal is a241 BRENDA localization in branch, click for list of all
endospore core is a
ensheathing process is a
envelope is a240 BRENDA localization in branch, click for list of all
epicuticle of collagen and cuticulin-based cuticle extracellular matrix is a
extracellular matrix is a239 BRENDA localization in branch, click for list of all
extracellular region is a224 BRENDA localization in branch, click for list of all
extrachromosomal circular DNA is a207 BRENDA localization in branch, click for list of all
extrachromosomal DNA is a206 BRENDA localization in branch, click for list of all
extrinsic component of membrane is a
fibrillar center is a
Flemming body is a
gas vesicle shell is a
germ tube is a204 BRENDA localization in branch, click for list of all
granular component is a203 BRENDA localization in branch, click for list of all
half bridge of spindle pole body is a
host cellular component is a
incipient cellular bud site is a
inclusion body is a188 BRENDA localization in branch, click for list of all
inner membrane pellicle complex is a
inner plaque of spindle pole body is a
intermediate layer of spindle pole body is a
intracellular immature spore is a
intrinsic component of membrane is a
investment cone is a
lateral element is a
lateral loop is a
lateral part of cell is a
leaflet of membrane bilayer is a
manchette is a178 BRENDA localization in branch, click for list of all
median body is a
membrane is a177 BRENDA localization in branch, click for list of all
membrane-enclosed lumen is a
metaphase plate is a115 BRENDA localization in branch, click for list of all
microtubule bundle is a
microtubule end is a114 BRENDA localization in branch, click for list of all
microtubule organizing center is a112 BRENDA localization in branch, click for list of all
midbody is a104 BRENDA localization in branch, click for list of all
myelin sheath is a103 BRENDA localization in branch, click for list of all
neck portion of tanycyte is a
nucleoid is a102 BRENDA localization in branch, click for list of all
nucleus lagging edge is a
nucleus leading edge is a
oral apparatus is a100 BRENDA localization in branch, click for list of all
organelle is a99 BRENDA localization in branch, click for list of all
intracellular organelle is a88 BRENDA localization in branch, click for list of all
eyespot apparatus is a
intracellular membrane-bounded organelle is a
attachment organelle is a24 BRENDA localization in branch, click for list of all
ER body is a23 BRENDA localization in branch, click for list of all
karyomere is a
nucleus is a22 BRENDA localization in branch, click for list of all
activated SUMO-E1 ligase complex part of
apolipoprotein B mRNA editing enzyme complex part of21 BRENDA localization in branch, click for list of all
ARC complex part of
ATF1-ATF4 transcription factor complex part of
ATF4-CREB1 transcription factor complex part of
ATR-ATRIP complex part of
BRCA1-A complex part of
BRCA1-B complex part of
BRCA1-C complex part of
BRCA1-Rad51 complex part of
BRCA2-BRAF35 complex part of
BRISC complex part of
CAK-ERCC2 complex part of
carboxy-terminal domain protein kinase complex part of
catenin-TCF7L2 complex part of
chromatin silencing complex part of
CLOCK-BMAL transcription complex part of
COP9 signalosome part of20 BRENDA localization in branch, click for list of all
core mediator complex part of
Cry-Per complex part of
CSL-Notch-Mastermind transcription factor complex part of
CURI complex part of
DNA helicase A complex part of
DNA ligase III-XRCC1 complex part of
DNA ligase IV complex part of
DNA-dependent protein kinase complex part of19 BRENDA localization in branch, click for list of all
DNA-dependent protein kinase-DNA ligase 4 complex part of
dosage compensation complex part of18 BRENDA localization in branch, click for list of all
E.F.G complex part of
exon-exon junction complex part of
FHL2-CREB complex part of
FHL3-CREB complex part of
GATA1-TAL1-TCF3-Lmo2 complex part of
GATA2-TAL1-TCF3-Lmo2 complex part of
generative cell nucleus is a
germ cell nucleus is a
female germ cell nucleus is a
germinal vesicle is a
male germ cell nucleus is a
Rhino-Deadlock-Cutoff Complex part of
heteromeric SMAD protein complex part of
histone pre-mRNA 3'end processing complex part of
integrator complex part of16 BRENDA localization in branch, click for list of all
Ku70:Ku80 complex part of
left nucleus is a
Lid2 complex part of
LinE complex part of
lobed nucleus is a
macronucleus is a15 BRENDA localization in branch, click for list of all
megasporocyte nucleus is a
Mei2 nuclear dot complex part of
micronucleus is a14 BRENDA localization in branch, click for list of all
microprocessor complex part of13 BRENDA localization in branch, click for list of all
microsporocyte nucleus is a
mitotic checkpoint complex part of
Mre11 complex part of12 BRENDA localization in branch, click for list of all
mRNA cap methyltransferase complex part of
MutLalpha complex part of
MutLbeta complex part of
MutSalpha complex part of
MutSbeta complex part of
MutSgamma complex part of
Noc complex part of
nuclear aryl hydrocarbon receptor complex part of
nuclear cyclin-dependent protein kinase holoenzyme complex part of
nuclear DNA-directed RNA polymerase complex part of
RNA polymerase III complex is a
RNA polymerase IV complex is a
RNA polymerase V complex is a
nuclear microtubule part of
nuclear RNA-directed RNA polymerase complex part of
nuclear stress granule part of
nuclear ubiquitin ligase complex part of
anaphase-promoting complex is a1 BRENDA localization in branch, click for list of all
BCOR complex is a
BRCA1-BARD1 complex is a
nuclear SCF ubiquitin ligase complex is a
PRC1 complex is a
SUMO-targeted ubiquitin ligase complex is a
nucleosome disassembly/reassembly complex part of
nucleotide-excision repair complex part of
NURS complex part of
P-TEFb-cap methyltransferase complex part of
PcG protein complex part of
PCNA-p21 complex part of
PDX1-PBX1b-MRG1 complex part of
primary endosperm nucleus is a
pronucleus is a8 BRENDA localization in branch, click for list of all
female pronucleus is a
male pronucleus is a6 BRENDA localization in branch, click for list of all
Rad51B-Rad51C complex part of
Rad51B-Rad51C-Rad51D-XRCC2 complex part of
Rad51C-XRCC3 complex part of
RC-1 DNA recombination complex part of
RCAF complex part of
RES complex part of
retrotransposon nucleocapsid part of
RGS6-DNMT1-DMAP1 complex part of
Rhp55-Rhp57 complex part of
right nucleus is a5 BRENDA localization in branch, click for list of all
small nuclear ribonucleoprotein complex part of
spliceosomal snRNP complex is a
penta-snRNP complex is a
SL snRNP is a
spliceosomal tri-snRNP complex is a
U1 snRNP is a3 BRENDA localization in branch, click for list of all
U11 snRNP is a
U11/U12 snRNP is a
U12 snRNP is a
U2 snRNP is a2 BRENDA localization in branch, click for list of all
U4 snRNP is a
U4atac snRNP is a
U5 snRNP is a1 BRENDA localization in branch, click for list of all
U6 snRNP is a
U6atac snRNP is a
U7 snRNP is a
SMC loading complex part of
SOSS complex part of
spliceosomal complex part of
SUMO activating enzyme complex part of
telomerase holoenzyme complex part of
THO complex part of
Tor2-Mei2-Ste11 complex part of
TRAMP complex part of
transcription export complex part of
transcription export complex 2 part of
transcription factor TFIIH core complex part of
tRNA-intron endonuclease complex part of
U2AF part of
upstream stimulatory factor complex part of
XRCC2-RAD51D complex part of
platelet dense tubular network is a
intracellular non-membrane-bounded organelle is a
intracellular vesicle is a
organelle subcompartment part of
organelle-enclosing lipid monolayer part of
zeta DNA polymerase complex part of
magnetosome is a1 BRENDA localization in branch, click for list of all
membrane-bounded organelle is a
non-membrane-bounded organelle is a
organelle membrane contact site part of
pellicle is a9 BRENDA localization in branch, click for list of all
periplasmic space is a8 BRENDA localization in branch, click for list of all
photoreceptor inner segment is a7 BRENDA localization in branch, click for list of all
polar tube is a6 BRENDA localization in branch, click for list of all
site of polarized growth is a
somatodendritic compartment is a
sperm head is a5 BRENDA localization in branch, click for list of all
sperm head-tail coupling apparatus is a
sporoplasm is a
subapical part of cell is a
supramolecular complex is a4 BRENDA localization in branch, click for list of all
symplast is a3 BRENDA localization in branch, click for list of all
tail portion of tanycyte is a
thylakoid is a2 BRENDA localization in branch, click for list of all
Yb body is a
intracellular is a78 BRENDA localization in branch, click for list of all
other organism part is a
protein-containing complex is a54 BRENDA localization in branch, click for list of all
virion is a9 BRENDA localization in branch, click for list of all
molecular_function is a